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    PRAMEF5 PRAME family member 5 [ Homo sapiens (human) ]

    Gene ID: 343068, updated on 18-Sep-2024

    Summary

    Official Symbol
    PRAMEF5provided by HGNC
    Official Full Name
    PRAME family member 5provided by HGNC
    Primary source
    HGNC:HGNC:27995
    See related
    Ensembl:ENSG00000270601 AllianceGenome:HGNC:27995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRAMEF23; PRAMEF5L
    Summary
    Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See PRAMEF5 in Genome Data Viewer
    Location:
    1p36.21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (13254198..13263435)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12695431..12704668)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13108514..13117751, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 18 Neighboring gene PRAME family member 31, pseudogene Neighboring gene PRAME family member 32, pseudogene Neighboring gene RNA, U6 small nuclear 771, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    PRAME family member 5
    Names
    PRAME family member 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013407.5NP_001013425.2  PRAME family member 5

      Status: VALIDATED

      Source sequence(s)
      AC244216
      Consensus CDS
      CCDS72708.1
      UniProtKB/Swiss-Prot
      A0A087WWD0, A2BDD6, A4FU31, A6NMV5, Q5TYX0
      UniProtKB/TrEMBL
      B7ZW04
      Related
      ENSP00000480122.1, ENST00000622421.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      13254198..13263435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_012132914.1 Reference GRCh38.p14 PATCHES

      Range
      408538..417775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_015495298.1 Reference GRCh38.p14 PATCHES

      Range
      220054..229291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187517.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      197666..206903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      12695431..12704668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)