U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    NANOS3 nanos C2HC-type zinc finger 3 [ Homo sapiens (human) ]

    Gene ID: 342977, updated on 2-May-2024

    Summary

    Official Symbol
    NANOS3provided by HGNC
    Official Full Name
    nanos C2HC-type zinc finger 3provided by HGNC
    Primary source
    HGNC:HGNC:22048
    See related
    Ensembl:ENSG00000187556 MIM:608229; AllianceGenome:HGNC:22048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOS3; NANOS1L; ZC2HC12C
    Summary
    Predicted to enable mRNA binding activity. Involved in germ cell development; negative regulation of translation; and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 1.4), brain (RPKM 1.0) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NANOS3 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13862036..13880757)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13988190..14006913)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13972850..13991571)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10212 Neighboring gene miR-23a/27a/24-2 cluster host gene Neighboring gene CRISPRi-validated cis-regulatory element chr19.2258 Neighboring gene microRNA 27a Neighboring gene microRNA 23a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14144 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:13958655-13958860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13964511-13965456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13975386-13976271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14148 Neighboring gene microRNA 181c Neighboring gene microRNA 181d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13993737-13994582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14000391-14000892 Neighboring gene break repair meiotic recombinase recruitment factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10218 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene MPRA-validated peak3378 silencer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC120114

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098622.3NP_001092092.1  nanos homolog 3

      See identical proteins and their annotated locations for NP_001092092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      AC020916, KF511254
      Consensus CDS
      CCDS42511.1
      UniProtKB/Swiss-Prot
      P60323, Q495E5
      Related
      ENSP00000341992.4, ENST00000339133.6
      Conserved Domains (2) summary
      pfam05741
      Location:77129
      zf-nanos; Nanos RNA binding domain
      cl25865
      Location:2474
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    RNA

    1. NR_146095.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC020916, CK821051
      Related
      ENST00000591727.1
    2. NR_146096.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC020916, BM702754, CK821051
    3. NR_146097.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC020916, CK821051

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      13862036..13880757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160022.1 Reference GRCh38.p14 PATCHES

      Range
      73877..92598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      13988190..14006913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)