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    ZKSCAN2 zinc finger with KRAB and SCAN domains 2 [ Homo sapiens (human) ]

    Gene ID: 342357, updated on 3-Apr-2024

    Summary

    Official Symbol
    ZKSCAN2provided by HGNC
    Official Full Name
    zinc finger with KRAB and SCAN domains 2provided by HGNC
    Primary source
    HGNC:HGNC:25677
    See related
    Ensembl:ENSG00000155592 AllianceGenome:HGNC:25677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF694; ZSCAN31; ZSCAN34
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 3.7), ovary (RPKM 2.1) and 24 other tissues See more
    Orthologs
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    Genomic context

    See ZKSCAN2 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (25236001..25257845, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (25515492..25537336, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (25247322..25269166, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 557, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10606 Neighboring gene aquaporin 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25268532-25269092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10608 Neighboring gene ZKSCAN2 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr16:25422594-25423095 Neighboring gene long intergenic non-protein coding RNA 2191 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:25453167-25454366 Neighboring gene CYCS pseudogene 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23199

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein with KRAB and SCAN domains 2
    Names
    zinc finger and SCAN domain containing 31
    zinc finger protein 694

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012981.5NP_001012999.3  zinc finger protein with KRAB and SCAN domains 2

      See identical proteins and their annotated locations for NP_001012999.3

      Status: VALIDATED

      Source sequence(s)
      AC008741, BC130007, BX648785, DB120548
      Consensus CDS
      CCDS32410.1
      UniProtKB/Swiss-Prot
      A1L3B4, Q63HK3, Q6ZN77
      UniProtKB/TrEMBL
      B4E0P9
      Related
      ENSP00000331626.7, ENST00000328086.12
      Conserved Domains (9) summary
      smart00431
      Location:41148
      SCAN; leucine rich region
      cd07765
      Location:227268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:248289
      KRAB; krueppel associated box
      COG5048
      Location:771957
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:777797
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:831853
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:41129
      SCAN; SCAN domain
      pfam13465
      Location:789813
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:497578
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      25236001..25257845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023200.3XP_016878689.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

      UniProtKB/TrEMBL
      B4DYF0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      25515492..25537336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380222.1XP_054236197.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1