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    OR6S1 olfactory receptor family 6 subfamily S member 1 [ Homo sapiens (human) ]

    Gene ID: 341799, updated on 17-Jun-2024

    Summary

    Official Symbol
    OR6S1provided by HGNC
    Official Full Name
    olfactory receptor family 6 subfamily S member 1provided by HGNC
    Primary source
    HGNC:HGNC:15363
    See related
    Ensembl:ENSG00000181803 AllianceGenome:HGNC:15363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR6S1Q; OR14-37
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See OR6S1 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20640696..20641691, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14837806..14838801, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21108855..21109850, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr (anticodon TGT) 4-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8083 Neighboring gene Sharpr-MPRA regulatory region 11977 Neighboring gene tRNA-Pro (anticodon TGG) 1-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:21110787-21111472 Neighboring gene uncharacterized LOC124903281 Neighboring gene tRNA-Tyr (anticodon GTA) 5-3 Neighboring gene tRNA-Tyr (anticodon GTA) 4-1

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of olfactory receptor, family 6, subfamily S, member 1 (OR6S1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    olfactory receptor 6S1
    Names
    olfactory receptor OR14-37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001968.1NP_001001968.1  olfactory receptor 6S1

      See identical proteins and their annotated locations for NP_001001968.1

      Status: PROVISIONAL

      Source sequence(s)
      BK004263
      Consensus CDS
      CCDS32038.1
      UniProtKB/Swiss-Prot
      Q6IFJ9, Q8NH40
      UniProtKB/TrEMBL
      A0A126GWN5
      Related
      ENSP00000313110.3, ENST00000320704.3
      Conserved Domains (2) summary
      pfam00001
      Location:43293
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33308
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      20640696..20641691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      14837806..14838801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)