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    POU2AF2 POU class 2 homeobox associating factor 2 [ Homo sapiens (human) ]

    Gene ID: 341032, updated on 13-Mar-2024

    Summary

    Official Symbol
    POU2AF2provided by HGNC
    Official Full Name
    POU class 2 homeobox associating factor 2provided by HGNC
    Primary source
    HGNC:HGNC:30527
    See related
    Ensembl:ENSG00000150750 MIM:620671; AllianceGenome:HGNC:30527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCAT1; OCA-T1; C11orf53
    Expression
    Biased expression in testis (RPKM 1.3), colon (RPKM 0.7) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See POU2AF2 in Genome Data Viewer
    Location:
    11q23.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111245725..111286401)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111255953..111296584)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111116450..111157126)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723966 Neighboring gene long intergenic non-protein coding RNA 2550 Neighboring gene ribosomal protein S17 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3894 Neighboring gene colorectal cancer associated 1 Neighboring gene POU class 2 homeobox associating factor 3 Neighboring gene uncharacterized LOC105369491

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC50104

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables POU domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    POU domain class 2-associating factor 2
    Names
    oct coactivator from tuft cells 1
    protein POU2AF2
    uncharacterized protein C11orf53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198498.3NP_940900.2  POU domain class 2-associating factor 2

      Status: VALIDATED

      Source sequence(s)
      AP002448
      Consensus CDS
      CCDS31674.2
      UniProtKB/Swiss-Prot
      A0A1C7CYV6, Q8IXP5
      Related
      ENSP00000280325.6, ENST00000280325.7
      Conserved Domains (1) summary
      pfam17721
      Location:55288
      DUF5566; Family of unknown function (DUF5566)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      111245725..111286401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542804.3XP_011541106.2  POU domain class 2-associating factor 2 isoform X1

      Related
      ENSP00000489630.1, ENST00000637637.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      111255953..111296584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368654.1XP_054224629.1  POU domain class 2-associating factor 2 isoform X1