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    DPPA5 developmental pluripotency associated 5 [ Homo sapiens (human) ]

    Gene ID: 340168, updated on 5-Mar-2024

    Summary

    Official Symbol
    DPPA5provided by HGNC
    Official Full Name
    developmental pluripotency associated 5provided by HGNC
    Primary source
    HGNC:HGNC:19201
    See related
    Ensembl:ENSG00000203909 MIM:611111; AllianceGenome:HGNC:19201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESG1
    Summary
    This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]
    Expression
    Biased expression in testis (RPKM 1.1), lung (RPKM 0.4) and 1 other tissue See more
    Orthologs
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    Genomic context

    See DPPA5 in Genome Data Viewer
    Location:
    6q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (73353063..73354276, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (74529750..74530963, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (74062786..74063999, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene syndecan binding protein 2 pseudogene 1 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 3 Neighboring gene MPRA-validated peak5896 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:74057704-74058208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:74058209-74058712 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:74058713-74059217 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:74059218-74059721 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:74063051-74063552 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:74063553-74064052 Neighboring gene KH domain containing 3 like, subcortical maternal complex member Neighboring gene OOEP antisense RNA 1 Neighboring gene oocyte expressed protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    developmental pluripotency-associated 5 protein
    Names
    embryonal stem cell specific gene 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025290.3NP_001020461.1  developmental pluripotency-associated 5 protein

      See identical proteins and their annotated locations for NP_001020461.1

      Status: REVIEWED

      Source sequence(s)
      AI365263, BC137549
      Consensus CDS
      CCDS34483.1
      UniProtKB/Swiss-Prot
      A6NC42, B2RPQ7
      Related
      ENSP00000359396.3, ENST00000370370.4
      Conserved Domains (1) summary
      pfam16005
      Location:1090
      MOEP19; KH-like RNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      73353063..73354276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      74529750..74530963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)