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    B4GALNT4 beta-1,4-N-acetyl-galactosaminyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 338707, updated on 23-Nov-2021

    Summary

    Official Symbol
    B4GALNT4provided by HGNC
    Official Full Name
    beta-1,4-N-acetyl-galactosaminyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:26315
    See related
    Ensembl:ENSG00000182272 MIM:618560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in brain (RPKM 7.9), ovary (RPKM 4.2) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See B4GALNT4 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (369499..382117)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (369499..382117)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376505 Neighboring gene CRISPRi-validated cis-regulatory element chr11.30 Neighboring gene plakophilin 3 Neighboring gene single Ig and TIR domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of beta-1,4-N-acetyl-galactosaminyl transferase 4 (B4GALNT4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • FLJ25045

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
    Names
    N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase
    NGalNAc-T1
    beta-1,4-N-acetyl-galactosaminyl transferase 4
    beta-1,4-N-acetylgalactosaminyltransferase IV
    beta1,4-N-acetylgalactosaminyltransferases IV
    beta4GalNAc-T4
    beta4GalNAcT4
    betaGT4
    NP_848632.2
    XP_016873143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178537.5NP_848632.2  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

      See identical proteins and their annotated locations for NP_848632.2

      Status: VALIDATED

      Source sequence(s)
      AB089939, AC138230, BF058197, CN348077
      Consensus CDS
      CCDS7694.1
      UniProtKB/Swiss-Prot
      Q76KP1
      Related
      ENSP00000328277.6, ENST00000329962.11
      Conserved Domains (2) summary
      cl08459
      Location:142263
      PA14; PA14 domain
      cl11394
      Location:7111020
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      369499..382117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017654.1XP_016873143.1  N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 isoform X1

    RNA

    1. XR_001747858.1 RNA Sequence

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