U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    DUSP29 dual specificity phosphatase 29 [ Homo sapiens (human) ]

    Gene ID: 338599, updated on 5-Mar-2024

    Summary

    Official Symbol
    DUSP29provided by HGNC
    Official Full Name
    dual specificity phosphatase 29provided by HGNC
    Primary source
    HGNC:HGNC:23481
    See related
    Ensembl:ENSG00000188716 MIM:618574; AllianceGenome:HGNC:23481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUPD1; FMDSP; DUSP27
    Summary
    Enables protein homodimerization activity and protein tyrosine/serine/threonine phosphatase activity. Involved in protein dephosphorylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    10q22.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75037472..75073642, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75911002..75947146, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76797230..76833400, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3598 Neighboring gene uncharacterized LOC124902459 Neighboring gene VISTA enhancer hs1500 Neighboring gene MPRA-validated peak1017 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76555535-76556121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76584665-76585436 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76585437-76586208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2504 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76615828-76616038 Neighboring gene lysine acetyltransferase 6B Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76630209-76630443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3601 Neighboring gene MPRA-validated peak1019 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3602 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76776654-76776821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76789883-76790382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3606 Neighboring gene small nucleolar RNA, C/D box 172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76817979-76818530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76829139-76829638 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:76836023-76836606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839714-76840274 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839152-76839713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76842102-76842602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76844610-76845110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76863200-76864044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76864045-76864889 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76865735-76866578 Neighboring gene peptidylprolyl isomerase A pseudogene 13 Neighboring gene dual specificity phosphatase 13B Neighboring gene dual specificity phosphatase 13A Neighboring gene sterile alpha motif domain containing 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide and gene-based association studies of anxiety disorders in European and african american samples.
    EBI GWAS Catalog
    Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity phosphatase 29
    Names
    atypical dual-specific protein phosphatase
    dual specificity phosphatase 27
    dual specificity phosphatase DUPD1
    dual specificity phosphatase and pro isomerase domain containing 1
    NP_001003892.1
    NP_001371838.1
    XP_016871665.1
    XP_054221695.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003892.3NP_001003892.1  dual specificity phosphatase 29

      See identical proteins and their annotated locations for NP_001003892.1

      Status: VALIDATED

      Source sequence(s)
      AC018511, AL392111
      Consensus CDS
      CCDS31223.1
      UniProtKB/Swiss-Prot
      B2RP93, Q68J44
      Related
      ENSP00000340609.5, ENST00000338487.6
      Conserved Domains (1) summary
      cd14575
      Location:45201
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1
    2. NM_001384909.1NP_001371838.1  dual specificity phosphatase 29

      Status: VALIDATED

      Source sequence(s)
      AC018511, AL392111
      Consensus CDS
      CCDS31223.1
      UniProtKB/Swiss-Prot
      B2RP93, Q68J44
      Conserved Domains (1) summary
      cd14575
      Location:45201
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      75037472..75073642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016176.2XP_016871665.1  dual specificity phosphatase 29 isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646202.1 Reference GRCh38.p14 PATCHES

      Range
      242148..263241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      75911002..75947146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365720.1XP_054221695.1  dual specificity phosphatase 29 isoform X1