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    Kdm7a lysine (K)-specific demethylase 7A [ Mus musculus (house mouse) ]

    Gene ID: 338523, updated on 2-Oct-2018

    Summary

    Official Symbol
    Kdm7aprovided by MGI
    Official Full Name
    lysine (K)-specific demethylase 7Aprovided by MGI
    Primary source
    MGI:MGI:2443388
    See related
    Ensembl:ENSMUSG00000042599 Vega:OTTMUSG00000022808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jhdm1d; BB041802; mKIAA1718; A630082K20Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 5.3), liver E14.5 (RPKM 4.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Kdm7a in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (39136620..39206773, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (39086619..39156772, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1, platelet Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene predicted gene, 38794 Neighboring gene predicted gene, 34147

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone demethylase activity (H3-K27 specific) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone demethylase activity (H3-K27 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    histone demethylase activity (H3-K36 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    histone demethylase activity (H3-K9 specific) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone demethylase activity (H3-K9 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    histone demethylase activity (H4-K20 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K27 demethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K27 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K36 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K9 demethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K9 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K20 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lysine-specific demethylase 7A
    Names
    jmjC domain-containing histone demethylation protein 1D
    jumonji C domain-containing histone demethylase 1 homolog D
    lysine-specific demethylase 7
    NP_001028602.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033430.4NP_001028602.2  lysine-specific demethylase 7A

      See identical proteins and their annotated locations for NP_001028602.2

      Status: VALIDATED

      Source sequence(s)
      AC153818, AK042834, AK129429, AW549902, BC145848
      Consensus CDS
      CCDS51753.1
      UniProtKB/Swiss-Prot
      Q3UWM4
      Related
      ENSMUSP00000002305.8, OTTMUSP00000026192, ENSMUST00000002305.8, OTTMUST00000054819
      Conserved Domains (3) summary
      smart00558
      Location:234297
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      cd15640
      Location:3988
      PHD_KDM7; PHD finger found in lysine-specific demethylase 7 (KDM7)
      cl21464
      Location:269369
      cupin_like; Conserved domain found in cupin and related proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      39136620..39206773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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