Format

Send to:

Choose Destination
    • Showing Current items.

    Kdm7a lysine (K)-specific demethylase 7A [ Mus musculus (house mouse) ]

    Gene ID: 338523, updated on 22-Aug-2021

    Summary

    Official Symbol
    Kdm7aprovided by MGI
    Official Full Name
    lysine (K)-specific demethylase 7Aprovided by MGI
    Primary source
    MGI:MGI:2443388
    See related
    Ensembl:ENSMUSG00000042599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kdm7; Jhdm1d; BB041802; mKIAA1718; A630082K20Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 5.3), liver E14.5 (RPKM 4.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kdm7a in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39113554..39183707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39136620..39206773, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (39086619..39156772, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1, platelet Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene predicted gene, 38794 Neighboring gene predicted gene, 34147

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3-methyl-lysine-36 demethylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3-methyl-lysine-9 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3-methyl-lysine-9 demethylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3-tri/di-methyl-lysine-27 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3-tri/di-methyl-lysine-27 demethylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4-methyl-lysine-20 demethylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3-K27 demethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K27 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-K36 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-K9 demethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K9 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K20 demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lysine-specific demethylase 7A
    Names
    jmjC domain-containing histone demethylation protein 1D
    jumonji C domain-containing histone demethylase 1 homolog D
    lysine-specific demethylase 7
    NP_001028602.2
    XP_036022151.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033430.4NP_001028602.2  lysine-specific demethylase 7A

      See identical proteins and their annotated locations for NP_001028602.2

      Status: VALIDATED

      Source sequence(s)
      AC153818, AK042834, AK129429, AW549902, BC145848
      Consensus CDS
      CCDS51753.1
      UniProtKB/Swiss-Prot
      Q3UWM4
      Related
      ENSMUSP00000002305.9, ENSMUST00000002305.9
      Conserved Domains (3) summary
      smart00558
      Location:234297
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      cd15640
      Location:3988
      PHD_KDM7; PHD finger found in lysine-specific demethylase 7 (KDM7)
      cl21464
      Location:269369
      cupin_like; Conserved domain found in cupin and related proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39113554..39183707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166258.1XP_036022151.1  lysine-specific demethylase 7A isoform X1

      Conserved Domains (1) summary
      pfam17811
      Location:11114
      JHD; Jumonji helical domain
    Support Center