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    Morc3 microrchidia 3 [ Mus musculus (house mouse) ]

    Gene ID: 338467, updated on 9-Dec-2024

    Summary

    Official Symbol
    Morc3provided by MGI
    Official Full Name
    microrchidia 3provided by MGI
    Primary source
    MGI:MGI:2136841
    See related
    Ensembl:ENSMUSG00000039456 AllianceGenome:MGI:2136841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NXP2; Zcwcc3; D16Jhu32e; 1110051N18Rik
    Summary
    Predicted to enable DNA binding activity; methylated histone binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within post-embryonic development. Located in PML body. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Morc3 in Genome Data Viewer
    Location:
    16 C4; 16 54.88 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (93629009..93672964)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (93832121..93876077)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5562 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:93711280-93711389 Neighboring gene STARR-positive B cell enhancer ABC_E1497 Neighboring gene STARR-seq mESC enhancer starr_41539 Neighboring gene predicted gene, 41501 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene RIKEN cDNA 2310043M15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:93798797-93799098 Neighboring gene STARR-positive B cell enhancer ABC_E7479 Neighboring gene STARR-seq mESC enhancer starr_41543 Neighboring gene predicted gene, 30881 Neighboring gene STARR-positive B cell enhancer ABC_E7480 Neighboring gene STARR-positive B cell enhancer ABC_E3176 Neighboring gene STARR-seq mESC enhancer starr_41545 Neighboring gene STARR-positive B cell enhancer ABC_E3177 Neighboring gene STARR-seq mESC enhancer starr_41548 Neighboring gene chromatin assembly factor 1, subunit B Neighboring gene STARR-positive B cell enhancer mm9_chr16:93914500-93914801 Neighboring gene STARR-positive B cell enhancer ABC_E10925 Neighboring gene STARR-seq mESC enhancer starr_41549 Neighboring gene claudin 14 Neighboring gene predicted gene, 31012

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MORC family CW-type zinc finger protein 3
    Names
    nuclear matrix protein 2
    zinc finger CW-type coiled-coil domain protein 3
    zinc finger, CW-type with coiled-coil domain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045529.3NP_001038994.2  MORC family CW-type zinc finger protein 3

      Status: VALIDATED

      Source sequence(s)
      AK172896, BC098072
      Consensus CDS
      CCDS79490.1
      UniProtKB/Swiss-Prot
      A6H605, F7BJB9, Q4QQR6, Q6A0C2, Q8R0R0
      Related
      ENSMUSP00000144369.2, ENSMUST00000202261.5
      Conserved Domains (4) summary
      pfam07496
      Location:409446
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:29136
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cl09111
      Location:768875
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl21462
      Location:698721
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      93629009..93672964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523060.4XP_006523123.1  MORC family CW-type zinc finger protein 3 isoform X1

      Conserved Domains (4) summary
      TIGR02168
      Location:629810
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07496
      Location:340377
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:180313
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
      cl00075
      Location:1466
      HATPase; Histidine kinase-like ATPase domain