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    Cog3 component of oligomeric golgi complex 3 [ Mus musculus (house mouse) ]

    Gene ID: 338337, updated on 2-Nov-2024

    Summary

    Official Symbol
    Cog3provided by MGI
    Official Full Name
    component of oligomeric golgi complex 3provided by MGI
    Primary source
    MGI:MGI:2450151
    See related
    Ensembl:ENSMUSG00000034893 AllianceGenome:MGI:2450151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430004N23
    Summary
    Predicted to be involved in several processes, including Golgi vesicle transport; protein glycosylation; and protein stabilization. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of Golgi transport complex. Is expressed in several structures, including brain; pancreas; and reproductive system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human COG3 (component of oligomeric golgi complex 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.2), CNS E14 (RPKM 8.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cog3 in Genome Data Viewer
    Location:
    14 D3; 14 40.29 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75939791..75992078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75702351..75754638, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36219 Neighboring gene glutamate rich 6B Neighboring gene predicted gene, 23622 Neighboring gene STARR-seq mESC enhancer starr_37146 Neighboring gene solute carrier family 25, member 30 Neighboring gene STARR-positive B cell enhancer ABC_E9050 Neighboring gene predicted gene, 36271

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Golgi transport complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    conserved oligomeric Golgi complex subunit 3
    Names
    COG complex subunit 3
    component of oligomeric golgi complex 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404684.1NP_001391613.1  conserved oligomeric Golgi complex subunit 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122285
    2. NM_177381.4NP_796355.2  conserved oligomeric Golgi complex subunit 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122285
      Consensus CDS
      CCDS36979.1
      UniProtKB/Swiss-Prot
      Q8CI04
      UniProtKB/TrEMBL
      E9QL65
      Related
      ENSMUSP00000045016.8, ENSMUST00000049168.9
      Conserved Domains (1) summary
      pfam04136
      Location:131274
      Sec34; Sec34-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      75939791..75992078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245092.3XP_011243394.1  conserved oligomeric Golgi complex subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam04136
      Location:150
      Sec34; Sec34-like family
    2. XM_006519148.5XP_006519211.1  conserved oligomeric Golgi complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8CI04
      Conserved Domains (1) summary
      pfam04136
      Location:131274
      Sec34; Sec34-like family