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    Hel25E Helicase at 25E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33781, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Hel25Eprovided by FlyBase
    Official Full Name
    Helicase at 25Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014189
    Locus tag
    Dmel_CG7269
    See related
    AllianceGenome:FB:FBgn0014189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7269; Dbp25F; dHel25E; Dmel\CG7269; DmRH4; hel; Hel; HEL; hel25E; HEL25E; jf26; l(2)25Eb; l(2)gdh-12; l(2)gdh12; l(2)jf26; l(2)k11511; sz; uap56; Uap56; UAP56; Wm6; WM6
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Involved in chromatin remodeling; mRNA export from nucleus; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Colocalizes with polytene chromosome. Is expressed in several structures, including egg chamber; embryonic/larval digestive system; embryonic/larval muscle system; embryonic/larval nervous system; and mitotic domain. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including DDX39A (DExD-box helicase 39A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Hel25E in Genome Data Viewer
    Location:
    25E6-25E6; 2-17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5539326..5542314, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5539326..5542314, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Chromosome associated protein D3 Neighboring gene tombola Neighboring gene uncharacterized protein Neighboring gene Lamin Neighboring gene oscillin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila gene encoding a DEAD box RNA helicase can suppress loss of wee1/mik1 function in Schizosaccharomyces pombe. Warbrick E, et al. Mol Gen Genet, 1994 Dec 1. PMID 7808417
    2. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α. Ochi N, et al. PLoS Genet, 2021 Dec. PMID 34871307, Free PMC Article
    3. Flanking genes of an essential gene give information about the evolution of metazoa. Zimek A, et al. Eur J Cell Biol, 2011 Apr. PMID 21163549
    4. UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization in Drosophila. Meignin C, et al. Dev Biol, 2008 Mar 1. PMID 18237727
    5. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
      Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
    2. Study presents evidence that UAP56 and Vas are cluster transcript binding proteins that organize a piRNA-processing compartment that spans the nuclear envelope.
      Title: UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.
    3. UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization.
      Title: UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription export complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    helicase at 25E
    Names
    CG7269-PA
    CG7269-PB
    CG7269-PC
    CG7269-PD
    Hel25E-PA
    Hel25E-PB
    Hel25E-PC
    Hel25E-PD
    RNA helicase
    helicase
    lethal(2)25Eb
    NP_001260100.1
    NP_723089.1
    NP_723090.1
    NP_723091.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5539326..5542314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164648.2 → NP_723091.1  helicase at 25E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723091.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27268, Q540X0, Q9VMQ1
      Related
      FBpp0078754
      Conserved Domains (2) summary
      cd18787
      Location:259 → 388
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17950
      Location:40 → 248
      DEADc_DDX39; DEAD-box helicase domain of DEAD box protein 39

    2. NM_164647.1 → NP_723090.1  helicase at 25E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27268, Q540X0, Q9VMQ1
      Related
      FBpp0078756, FBtr0079125
      Conserved Domains (2) summary
      cd18787
      Location:259 → 388
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17950
      Location:40 → 248
      DEADc_DDX39; DEAD-box helicase domain of DEAD box protein 39

    3. NM_001273171.1 → NP_001260100.1  helicase at 25E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260100.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC90
      Conserved Domains (2) summary
      smart00487
      Location:56 → 243
      DEXDc; DEAD-like helicases superfamily
      cd00268
      Location:43 → 242
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    4. NM_164646.3 → NP_723089.1  helicase at 25E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723089.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27268, Q540X0, Q9VMQ1
      Related
      FBpp0078755
      Conserved Domains (2) summary
      cd18787
      Location:259 → 388
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cd17950
      Location:40 → 248
      DEADc_DDX39; DEAD-box helicase domain of DEAD box protein 39
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC90 M9PC90
    Q27268.1 Q27268

    Gene LinkOut

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