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    IARS1 isoleucyl-tRNA synthetase 1 [ Homo sapiens (human) ]

    Gene ID: 3376, updated on 8-Jul-2021

    Summary

    Official Symbol
    IARS1provided by HGNC
    Official Full Name
    isoleucyl-tRNA synthetase 1provided by HGNC
    Primary source
    HGNC:HGNC:5330
    See related
    Ensembl:ENSG00000196305 MIM:600709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRS; IARS; ILRS; ILERS; GRIDHH; PRO0785
    Summary
    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 50.6), appendix (RPKM 20.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See IARS1 in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (92210207..92293697, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (94972489..95055979, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BEN domain containing 3 pseudogene 2 Neighboring gene uncharacterized LOC112268048 Neighboring gene serine protease 47, pseudogene Neighboring gene microRNA 3651 Neighboring gene small nucleolar RNA, H/ACA box 84 Neighboring gene phagosome assembly factor 1 pseudogene Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify isoleucyl-tRNA synthetase (IARS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify isoleucyl-tRNA synthetase (IARS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify isoleucyl-tRNA synthetase (IARS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify isoleucyl-tRNA synthetase (IARS), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    matrix gag HIV-1 MA is identified to have a physical interaction with isoleucyl-tRNA synthetase (IARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20736, FLJ41915, FLJ45144

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables isoleucine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables isoleucine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    Names
    isoleucine tRNA ligase 1, cytoplasmic
    NP_001361228.1
    NP_001361229.1
    NP_001361230.1
    NP_001365498.1
    NP_001365500.1
    NP_001365501.1
    NP_001365502.1
    NP_001365503.1
    NP_001365504.1
    NP_001365505.1
    NP_001365506.1
    NP_001365507.1
    NP_001365508.1
    NP_001365509.1
    NP_001365511.1
    NP_001365512.1
    NP_001365513.1
    NP_001365514.1
    NP_001365515.1
    NP_002152.2
    NP_038203.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051498.1 RefSeqGene

      Range
      5001..88550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001374299.1NP_001361228.1  isoleucine--tRNA ligase, cytoplasmic isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Related
      ENSP00000508205.1, ENST00000684557.1
      Conserved Domains (1) summary
      PLN02882
      Location:61046
      PLN02882; aminoacyl-tRNA ligase
    2. NM_001374300.1NP_001361229.1  isoleucine--tRNA ligase, cytoplasmic isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61046
      PLN02882; aminoacyl-tRNA ligase
    3. NM_001374301.1NP_001361230.1  isoleucine--tRNA ligase, cytoplasmic isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61043
      PLN02882; aminoacyl-tRNA ligase
    4. NM_001378569.1NP_001365498.1  isoleucine--tRNA ligase, cytoplasmic isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61092
      PLN02882; aminoacyl-tRNA ligase
    5. NM_001378571.1NP_001365500.1  isoleucine--tRNA ligase, cytoplasmic isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61078
      PLN02882; aminoacyl-tRNA ligase
    6. NM_001378572.1NP_001365501.1  isoleucine--tRNA ligase, cytoplasmic isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    7. NM_001378573.1NP_001365502.1  isoleucine--tRNA ligase, cytoplasmic isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    8. NM_001378574.1NP_001365503.1  isoleucine--tRNA ligase, cytoplasmic isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    9. NM_001378575.1NP_001365504.1  isoleucine--tRNA ligase, cytoplasmic isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Related
      ENSP00000507144.1, ENST00000683565.1
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    10. NM_001378576.1NP_001365505.1  isoleucine--tRNA ligase, cytoplasmic isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    11. NM_001378577.1NP_001365506.1  isoleucine--tRNA ligase, cytoplasmic isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Related
      ENSP00000506798.1, ENST00000682578.1
      Conserved Domains (1) summary
      PLN02882
      Location:61143
      PLN02882; aminoacyl-tRNA ligase
    12. NM_001378578.1NP_001365507.1  isoleucine--tRNA ligase, cytoplasmic isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Related
      ENSP00000507577.1, ENST00000683679.1
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    13. NM_001378579.1NP_001365508.1  isoleucine--tRNA ligase, cytoplasmic isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Related
      ENSP00000507286.1, ENST00000683469.1
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    14. NM_001378580.1NP_001365509.1  isoleucine--tRNA ligase, cytoplasmic isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    15. NM_001378582.1NP_001365511.1  isoleucine--tRNA ligase, cytoplasmic isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61039
      PLN02882; aminoacyl-tRNA ligase
    16. NM_001378583.1NP_001365512.1  isoleucine--tRNA ligase, cytoplasmic isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61030
      PLN02882; aminoacyl-tRNA ligase
    17. NM_001378584.1NP_001365513.1  isoleucine--tRNA ligase, cytoplasmic isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61046
      PLN02882; aminoacyl-tRNA ligase
    18. NM_001378585.1NP_001365514.1  isoleucine--tRNA ligase, cytoplasmic isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    19. NM_001378586.1NP_001365515.1  isoleucine--tRNA ligase, cytoplasmic isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Related
      ENSP00000415020.3, ENST00000447699.7
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    20. NM_002161.6NP_002152.2  isoleucine--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_002152.2

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Consensus CDS
      CCDS6694.1
      UniProtKB/Swiss-Prot
      P41252
      UniProtKB/TrEMBL
      Q6P0M4, Q7L4K8
      Related
      ENSP00000406448.4, ENST00000443024.7
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase
    21. NM_013417.4NP_038203.2  isoleucine--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_038203.2

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Consensus CDS
      CCDS6694.1
      UniProtKB/Swiss-Prot
      P41252
      Related
      ENSP00000364794.3, ENST00000375643.7
      Conserved Domains (1) summary
      PLN02882
      Location:61071
      PLN02882; aminoacyl-tRNA ligase

    RNA

    1. NR_073446.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136097
      Related
      ENST00000627121.3

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      92210207..92293697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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