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    N4bp2 NEDD4 binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 333789, updated on 23-Jun-2021

    Summary

    Official Symbol
    N4bp2provided by MGI
    Official Full Name
    NEDD4 binding protein 2provided by MGI
    Primary source
    MGI:MGI:2684414
    See related
    Ensembl:ENSMUSG00000037795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B3b; B3bp; Gm868; Gm1791; E430014I16
    Expression
    Broad expression in CNS E11.5 (RPKM 6.8), limb E14.5 (RPKM 6.3) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See N4bp2 in Genome Data Viewer
    Location:
    5; 5 C3.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65909462..65987450)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65760510..65830107)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (66154760..66218023)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40309 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene PDS5 cohesin associated factor A Neighboring gene predicted gene, 24399 Neighboring gene predicted gene 5296 Neighboring gene predicted gene 3521 Neighboring gene ras homolog family member H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    NEDD4-binding protein 2
    Names
    Bcl3 binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024917.1NP_001020088.1  NEDD4-binding protein 2

      See identical proteins and their annotated locations for NP_001020088.1

      Status: VALIDATED

      Source sequence(s)
      AK173167, BC054549, CK637074, CX769144
      Consensus CDS
      CCDS19310.1
      UniProtKB/TrEMBL
      F8VQG7, Q69ZK1
      Related
      ENSMUSP00000143807.2, ENSMUST00000201489.4
      Conserved Domains (4) summary
      smart00463
      Location:15961678
      SMR; Small MutS-related domain
      COG5099
      Location:92253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:15291590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372498
      AAA_33; AAA domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      65909462..65987450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254611.2XP_030110471.1  NEDD4-binding protein 2 isoform X2

      Conserved Domains (5) summary
      smart00463
      Location:16761758
      SMR; Small MutS-related domain
      COG5099
      Location:172333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:4787
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16091670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452578
      AAA_33; AAA domain
    2. XM_036165236.1XP_036021129.1  NEDD4-binding protein 2 isoform X3

      Conserved Domains (4) summary
      smart00463
      Location:15961678
      SMR; Small MutS-related domain
      COG5099
      Location:92253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:15291590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372498
      AAA_33; AAA domain
    3. XM_030254610.2XP_030110470.1  NEDD4-binding protein 2 isoform X2

      Conserved Domains (5) summary
      smart00463
      Location:16761758
      SMR; Small MutS-related domain
      COG5099
      Location:172333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:4787
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16091670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452578
      AAA_33; AAA domain
    4. XM_006504004.5XP_006504067.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504067.1

      Conserved Domains (5) summary
      smart00463
      Location:17031785
      SMR; Small MutS-related domain
      COG5099
      Location:199360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16361697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479605
      AAA_33; AAA domain
    5. XM_030254615.2XP_030110475.1  NEDD4-binding protein 2 isoform X3

      Conserved Domains (4) summary
      smart00463
      Location:15961678
      SMR; Small MutS-related domain
      COG5099
      Location:92253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:15291590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372498
      AAA_33; AAA domain
    6. XM_006504003.3XP_006504066.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504066.1

      Conserved Domains (5) summary
      smart00463
      Location:17031785
      SMR; Small MutS-related domain
      COG5099
      Location:199360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16361697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479605
      AAA_33; AAA domain
    7. XM_006504007.4XP_006504070.1  NEDD4-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006504070.1

      UniProtKB/TrEMBL
      F8VQG7
      Related
      ENSMUSP00000084519.4, ENSMUST00000087264.4
      Conserved Domains (4) summary
      smart00463
      Location:15961678
      SMR; Small MutS-related domain
      COG5099
      Location:92253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:15291590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372498
      AAA_33; AAA domain
    8. XM_006504006.5XP_006504069.1  NEDD4-binding protein 2 isoform X2

      Conserved Domains (5) summary
      smart00463
      Location:16761758
      SMR; Small MutS-related domain
      COG5099
      Location:172333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:4787
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16091670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452578
      AAA_33; AAA domain
    9. XM_030254614.1XP_030110474.1  NEDD4-binding protein 2 isoform X3

      Conserved Domains (4) summary
      smart00463
      Location:15961678
      SMR; Small MutS-related domain
      COG5099
      Location:92253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:15291590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372498
      AAA_33; AAA domain
    10. XM_030254609.2XP_030110469.1  NEDD4-binding protein 2 isoform X2

      Conserved Domains (5) summary
      smart00463
      Location:16761758
      SMR; Small MutS-related domain
      COG5099
      Location:172333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:4787
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16091670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452578
      AAA_33; AAA domain
    11. XM_030254612.1XP_030110472.1  NEDD4-binding protein 2 isoform X3

      Conserved Domains (4) summary
      smart00463
      Location:15961678
      SMR; Small MutS-related domain
      COG5099
      Location:92253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:15291590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372498
      AAA_33; AAA domain
    12. XM_030254613.1XP_030110473.1  NEDD4-binding protein 2 isoform X3

      Conserved Domains (4) summary
      smart00463
      Location:15961678
      SMR; Small MutS-related domain
      COG5099
      Location:92253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:15291590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372498
      AAA_33; AAA domain
    13. XM_011240752.3XP_011239054.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011239054.1

      Conserved Domains (5) summary
      smart00463
      Location:17031785
      SMR; Small MutS-related domain
      COG5099
      Location:199360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16361697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479605
      AAA_33; AAA domain
    14. XM_006504005.4XP_006504068.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504068.1

      Conserved Domains (5) summary
      smart00463
      Location:17031785
      SMR; Small MutS-related domain
      COG5099
      Location:199360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:16361697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479605
      AAA_33; AAA domain
    15. XM_017320937.2XP_017176426.1  NEDD4-binding protein 2 isoform X4

      Conserved Domains (2) summary
      smart00463
      Location:11051187
      SMR; Small MutS-related domain
      pfam08590
      Location:10381099
      DUF1771; Domain of unknown function (DUF1771)
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