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    HSP90AA1 heat shock protein 90 alpha family class A member 1 [ Homo sapiens (human) ]

    Gene ID: 3320, updated on 7-Apr-2024

    Summary

    Official Symbol
    HSP90AA1provided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class A member 1provided by HGNC
    Primary source
    HGNC:HGNC:5253
    See related
    Ensembl:ENSG00000080824 MIM:140571; AllianceGenome:HGNC:5253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
    Summary
    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in brain (RPKM 360.6), testis (RPKM 312.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HSP90AA1 in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102080742..102139749, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96316329..96375332, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102547079..102606086, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene uncharacterized LOC107984661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102515797-102516781 Neighboring gene Sharpr-MPRA regulatory region 9666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102522673-102523378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102523379-102524082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102530418-102531305 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102550057-102551256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6107 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6110 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102605474-102605669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102622168-102623084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102623085-102624001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102625184-102625684 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:102638165-102639150 Neighboring gene WD repeat domain 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102650679-102651180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102651181-102651680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6111 Neighboring gene uncharacterized LOC105370677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MOK protein kinase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
    Nef nef Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression PubMed
    Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat Hyperthermia (39.5C) increases expression of HSP90 protein in CD4+ T cells, which enhances HIV-1 Tat-mediated transactivation of the LTR. Hyperthermia also increases single-cycle HIV-1 infection PubMed
    tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
    tat Hsp90 chaperone activity is required for HIV-1 Tat transport through the endosome membrane PubMed
    tat Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat PubMed
    tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    Vif vif HIV-1 Vif interacts with HSP90AA1; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1) at amino acid residues 473-474 and 491-492 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31884

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity TAS
    Traceable Author Statement
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables CTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables MHC class II protein complex binding HDA PubMed 
    enables RNA binding HDA PubMed 
    enables Rho GDP-dissociation inhibitor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TPR domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TPR domain binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables UTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables disordered domain specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nitric-oxide synthase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sulfonylurea receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chaperone-mediated autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chaperone-mediated protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of defense response to virus by host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tau-protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein insertion into mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein refolding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein unfolding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein-containing complex assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to salt stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telomerase holoenzyme complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in lysosomal lumen TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in sperm mitochondrial sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heat shock protein HSP 90-alpha
    Names
    HSP 86
    LPS-associated protein 2
    epididymis luminal secretory protein 52
    epididymis secretory sperm binding protein Li 65p
    heat shock 86 kDa
    heat shock 90kD protein 1, alpha
    heat shock 90kD protein 1, alpha-like 4
    heat shock 90kD protein, alpha-like 4
    heat shock 90kDa protein 1, alpha
    heat shock protein 90kDa alpha (cytosolic), class A member 1
    heat shock protein 90kDa alpha family class A member 1
    lipopolysaccharide-associated protein 2
    renal carcinoma antigen NY-REN-38
    NP_001017963.2
    NP_005339.3
    XP_011535020.1
    XP_054231954.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017963.3NP_001017963.2  heat shock protein HSP 90-alpha isoform 1

      See identical proteins and their annotated locations for NP_001017963.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI250920, AJ890083, BX248761, DA237149
      Consensus CDS
      CCDS32160.1
      UniProtKB/Swiss-Prot
      P07900
      UniProtKB/TrEMBL
      Q86SX1
      Related
      ENSP00000335153.7, ENST00000334701.11
      Conserved Domains (3) summary
      smart00387
      Location:162313
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:140854
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:318844
      HSP90; Hsp90 protein
    2. NM_005348.4NP_005339.3  heat shock protein HSP 90-alpha isoform 2

      See identical proteins and their annotated locations for NP_005339.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AI250920, AJ890083, DC303876
      Consensus CDS
      CCDS9967.1
      UniProtKB/Swiss-Prot
      A8K500, B3KPJ9, P07900, Q2PP14, Q5CAQ6, Q5CAQ7, Q9BVQ5
      UniProtKB/TrEMBL
      K9JA46, Q8TBA7
      Related
      ENSP00000216281.8, ENST00000216281.13
      Conserved Domains (1) summary
      PTZ00272
      Location:18732
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102080742..102139749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536718.3XP_011535020.1  heat shock protein HSP 90-alpha isoform X1

      Conserved Domains (3) summary
      smart00387
      Location:161312
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:139853
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:317843
      HSP90; Hsp90 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      96316329..96375332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375979.1XP_054231954.1  heat shock protein HSP 90-alpha isoform X1