HSP90AA1 heat shock protein 90 alpha family class A member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSP90AA1provided by HGNC
Official Full Name: heat shock protein 90 alpha family class A member 1provided by HGNC
Primary source: HGNC:HGNC:5253
See related: Ensembl:ENSG00000080824 MIM:140571; AllianceGenome:HGNC:5253
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
Summary: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression: Ubiquitous expression in brain (RPKM 360.6), testis (RPKM 312.5) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 14q32.31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (102080742..102139749, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (96316329..96375332, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (102547079..102606086, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody.
Title: NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody.
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
Title: HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
Updates on Abeta Processing by Hsp90, BRICHOS, and Newly Reported Distinctive Chaperones.
Title: Updates on Aβ Processing by Hsp90, BRICHOS, and Newly Reported Distinctive Chaperones.
Heat Shock Protein 90 in Parkinson's Disease: Profile of a Serial Killer.
Title: Heat Shock Protein 90 in Parkinson's Disease: Profile of a Serial Killer.
Mutations F352A and Y528A in human HSP90alpha reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Title: Mutations F352A and Y528A in human HSP90α reduce fibronectin association and fibrillogenesis in cell-derived matrices.
PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK/NF-kappaB pathway and PD-L1 expression.
Title: PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK/NF-κB pathway and PD-L1 expression.
SIRT1 and HSP90alpha feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas.
Title: SIRT1 and HSP90α feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas.
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma.
Title: HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma.
USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
Title: USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90alpha and Hsp90beta.
Title: Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90α and Hsp90β.

Submit: New GeneRIF Correction See all GeneRIFs (485)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Gag-Pol	gag-pol	HSP90 is incorporated into HIV-1 GagPol virus-like particles	PubMed
Nef	nef	Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression	PubMed
Pr55(Gag)	gag	HSP90 is incorporated into HIV-1 Gag virus-like particles	PubMed
Tat	tat	Hyperthermia (39.5C) increases expression of HSP90 protein in CD4+ T cells, which enhances HIV-1 Tat-mediated transactivation of the LTR. Hyperthermia also increases single-cycle HIV-1 infection	PubMed
	tat	HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells	PubMed
	tat	Hsp90 chaperone activity is required for HIV-1 Tat transport through the endosome membrane	PubMed
	tat	Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat	PubMed
	tat	Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation	PubMed
Vif	vif	HIV-1 Vif interacts with HSP90AA1; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1) at amino acid residues 473-474 and 491-492 by the HIV-1 protease	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HSPCAL3__6605 (e-PCR)
- UniSTS:463618

G35354 (e-PCR)
- UniSTS:47393

D3S4173 (e-PCR)
- UniSTS:43598

G35909 (e-PCR)
- UniSTS:20576

G35702 (e-PCR)
- UniSTS:8035

RH75563 (e-PCR)
- UniSTS:92017

WI-19188 (e-PCR)
- UniSTS:73872

PMC134733P3 (e-PCR)
- UniSTS:270751

PMC134733P4 (e-PCR)
- UniSTS:270752

PMC134733P5 (e-PCR)
- UniSTS:270753

GDB:201870 (e-PCR)
- UniSTS:156070

RH78019 (e-PCR)
- UniSTS:91566

HSPCA_3204 (e-PCR)
- UniSTS:462258

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables AP-3 adaptor complex binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	TAS Traceable Author Statement more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables CTP binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables MHC class II protein complex binding	HDA more info	PubMed
enables RNA binding	HDA more info	PubMed
enables Rho GDP-dissociation inhibitor binding	IEA Inferred from Electronic Annotation more info
enables TPR domain binding	IDA Inferred from Direct Assay more info	PubMed
enables TPR domain binding	TAS Traceable Author Statement more info	PubMed
enables UTP binding	IEA Inferred from Electronic Annotation more info
enables dATP binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme-substrate adaptor activity	EXP Inferred from Experiment more info	PubMed
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase regulator activity	EXP Inferred from Experiment more info	PubMed
enables nitric-oxide synthase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables nitric-oxide synthase regulator activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfonylurea receptor binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated autophagy	TAS Traceable Author Statement more info	PubMed
involved_in chaperone-mediated protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein complex assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial transport	TAS Traceable Author Statement more info	PubMed
involved_in neurofibrillary tangle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide metabolic process	TAS Traceable Author Statement more info
involved_in positive regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of telomere maintenance via telomerase	TAS Traceable Author Statement more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
involved_in protein refolding	TAS Traceable Author Statement more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein unfolding	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in response to antibiotic	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to cold	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to salt stress	IEA Inferred from Electronic Annotation more info
involved_in response to unfolded protein	NAS Non-traceable Author Statement more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in telomerase holoenzyme complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in telomerase holoenzyme complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect telomere maintenance via telomerase	IDA Inferred from Direct Assay more info	PubMed
involved_in telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic growth cone	IEA Inferred from Electronic Annotation more info
located_in dendritic growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	IEA Inferred from Electronic Annotation more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in lysosomal lumen	TAS Traceable Author Statement more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein folding chaperone complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
located_in secretory granule lumen	IEA Inferred from Electronic Annotation more info
located_in secretory granule lumen	TAS Traceable Author Statement more info
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
located_in sperm mitochondrial sheath	IEA Inferred from Electronic Annotation more info
located_in sperm plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein HSP 90-alpha

Names: HSP 86; LPS-associated protein 2; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein family C member 1; lipopolysaccharide-associated protein 2; renal carcinoma antigen NY-REN-38

NP_001017963.2

EC 3.6.4.10

NP_005339.3

EC 3.6.4.10

XP_011535020.1

EC 3.6.4.10

XP_054231954.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017963.3 → NP_001017963.2 heat shock protein HSP 90-alpha isoform 1

See identical proteins and their annotated locations for NP_001017963.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI250920, AJ890083, BX248761, DA237149

Consensus CDS

CCDS32160.1

UniProtKB/Swiss-Prot

P07900

UniProtKB/TrEMBL

Q86SX1

Related

ENSP00000335153.7, ENST00000334701.11

Conserved Domains (3) summary

smart00387
Location:162 → 313

HATPase_c; Histidine kinase-like ATPases

PTZ00272
Location:140 → 854

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:318 → 844

HSP90; Hsp90 protein
NM_005348.4 → NP_005339.3 heat shock protein HSP 90-alpha isoform 2

See identical proteins and their annotated locations for NP_005339.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AI250920, AJ890083, DC303876

Consensus CDS

CCDS9967.1

UniProtKB/Swiss-Prot

A8K500, B3KPJ9, P07900, Q2PP14, Q5CAQ6, Q5CAQ7, Q9BVQ5

UniProtKB/TrEMBL

K9JA46, Q8TBA7

Related

ENSP00000216281.8, ENST00000216281.13

Conserved Domains (1) summary

PTZ00272
Location:18 → 732

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

102080742..102139749 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536718.3 → XP_011535020.1 heat shock protein HSP 90-alpha isoform X1

Conserved Domains (3) summary

smart00387
Location:161 → 312

HATPase_c; Histidine kinase-like ATPases

PTZ00272
Location:139 → 853

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:317 → 843

HSP90; Hsp90 protein