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    Dgkk diacylglycerol kinase kappa [ Mus musculus (house mouse) ]

    Gene ID: 331374, updated on 8-Dec-2018

    Summary

    Official Symbol
    Dgkkprovided by MGI
    Official Full Name
    diacylglycerol kinase kappaprovided by MGI
    Primary source
    MGI:MGI:3580254
    See related
    Ensembl:ENSMUSG00000062393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm360
    Annotation information
    Note: This gene aligns across a gap in the GRCm38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_039699.8 and the 3' end was annotated on NT_039700.8 in NCBI's Mus Musculus Annotation Release 105. [15 Jun 2015]
    Annotation category: suggests misassembly
    Expression
    Biased expression in CNS E18 (RPKM 1.2), CNS E14 (RPKM 0.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Dgkk in Genome Data Viewer
    Location:
    X; X A1.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (6779306..6948363)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (6356432..6356762) , (6450607..6525489)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 15 Neighboring gene RIKEN cDNA 5430428K19 gene Neighboring gene shroom family member 4 Neighboring gene cyclin B3 Neighboring gene A kinase (PRKA) anchor protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    lipid phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase kappa
    NP_808582.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177914.3NP_808582.3  diacylglycerol kinase kappa

      Status: VALIDATED

      Source sequence(s)
      AL671962, AW121906, BC075627
      Consensus CDS
      CCDS85745.1
      UniProtKB/TrEMBL
      E9Q7N4, Q6DIC8
      Related
      ENSMUSP00000067591.7, ENSMUST00000067410.13
      Conserved Domains (5) summary
      smart00046
      Location:336458
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:170219
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:60154
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:59147
      PH; PH domain
      cl02440
      Location:703860
      DAGK_acc; Diacylglycerol kinase accessory domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      6779306..6948363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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