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    HSPA6 heat shock protein family A (Hsp70) member 6 [ Homo sapiens (human) ]

    Gene ID: 3310, updated on 17-Jun-2024

    Summary

    Official Symbol
    HSPA6provided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 6provided by HGNC
    Primary source
    HGNC:HGNC:5239
    See related
    Ensembl:ENSG00000173110 MIM:140555; AllianceGenome:HGNC:5239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP70B'
    Summary
    Enables enzyme binding activity; heat shock protein binding activity; and unfolded protein binding activity. Involved in cellular response to heat and protein refolding. Located in centriole and cytosol. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HSPA6 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161524540..161526894)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160787168..160789522)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161494330..161496684)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc gamma receptor IIa Neighboring gene tRNA-Asp (GTC) 10-1 Neighboring gene tRNA-Gly (anticodon GCC) 2-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1481 Neighboring gene tRNA-Leu (anticodon CAG) 1-6 Neighboring gene tRNA-Gly (anticodon TCC) 2-6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of genetic loci associated with Helicobacter pylori serologic status.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp160 is identified to have a physical interaction with heat shock 70kDa protein 6 (HSPA6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Nef nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
    Pr55(Gag) gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed
    gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
    Tat tat HIV-1 and the viral protein Tat modulate the expression of heat shock 70kDa protein 6 (HSPA6; HSP70B') in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    Vpr vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
    vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
    matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT involved_in cellular heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in blood microparticle HDA PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    heat shock 70 kDa protein 6
    Names
    epididymis secretory sperm binding protein
    heat shock 70 kDa protein B'
    heat shock 70kD protein 6 (HSP70B')
    heat shock 70kDa protein 6 (HSP70B')

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002155.5NP_002146.2  heat shock 70 kDa protein 6

      See identical proteins and their annotated locations for NP_002146.2

      Status: VALIDATED

      Source sequence(s)
      AK093925, AL590385, BC035665, CD366171
      Consensus CDS
      CCDS1231.1
      UniProtKB/Swiss-Prot
      P17066, Q1HBA8, Q8IYK7, Q9BT95
      UniProtKB/TrEMBL
      A0A384NKX5, B2R6X5, B3KSM6
      Related
      ENSP00000310219.4, ENST00000309758.6
      Conserved Domains (1) summary
      cl26953
      Location:8643
      HSP70; Hsp70 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161524540..161526894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160787168..160789522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)