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    HSPA2 heat shock protein family A (Hsp70) member 2 [ Homo sapiens (human) ]

    Gene ID: 3306, updated on 7-Jan-2024

    Summary

    Official Symbol
    HSPA2provided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 2provided by HGNC
    Primary source
    HGNC:HGNC:5235
    See related
    Ensembl:ENSG00000126803 MIM:140560; AllianceGenome:HGNC:5235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP70-2; HSP70-3
    Summary
    Enables disordered domain specific binding activity; enzyme binding activity; and unfolded protein binding activity. Involved in negative regulation of inclusion body assembly and protein refolding. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Genomic context

    See HSPA2 in Genome Data Viewer
    Location:
    14q23.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64535905..64543237)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58743704..58751035)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65002623..65009955)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5834 Neighboring gene A-kinase anchoring protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5835 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64970928-64971598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5837 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5839 Neighboring gene protein phosphatase 1 regulatory subunit 36 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65039864-65040400 Neighboring gene nucleoporin 50 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Nef nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
    Pr55(Gag) gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed
    gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
    Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock 70kDa protein 2 (HSPA2, HSP70-2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
    vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
    matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables glycolipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in male meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male meiotic nuclear division TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of inclusion body assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptonemal complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CatSper complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in blood microparticle HDA PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in meiotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heat shock-related 70 kDa protein 2
    Names
    epididymis secretory sperm binding protein
    heat shock 70kD protein 2
    heat shock 70kDa protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387931.1NP_001374860.1  heat shock-related 70 kDa protein 2

      Status: VALIDATED

      Source sequence(s)
      AL049869
      Consensus CDS
      CCDS9766.1
      UniProtKB/Swiss-Prot
      P54652, Q15508, Q53XM3, Q9UE78
      UniProtKB/TrEMBL
      A0A384MDT7
      Related
      ENSP00000378199.1, ENST00000394709.2
      Conserved Domains (1) summary
      PTZ00009
      Location:2615
      PTZ00009; heat shock 70 kDa protein; Provisional
    2. NM_021979.4NP_068814.2  heat shock-related 70 kDa protein 2

      See identical proteins and their annotated locations for NP_068814.2

      Status: VALIDATED

      Source sequence(s)
      BC001752, BC036107, CD300159, CN356507, DB042367
      Consensus CDS
      CCDS9766.1
      UniProtKB/Swiss-Prot
      P54652, Q15508, Q53XM3, Q9UE78
      UniProtKB/TrEMBL
      A0A384MDT7
      Related
      ENSP00000247207.6, ENST00000247207.7
      Conserved Domains (1) summary
      PTZ00009
      Location:2615
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      64535905..64543237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      58743704..58751035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)