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    HSPA2 heat shock protein family A (Hsp70) member 2 [ Homo sapiens (human) ]

    Gene ID: 3306, updated on 20-Oct-2020

    Summary

    Official Symbol
    HSPA2provided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 2provided by HGNC
    Primary source
    HGNC:HGNC:5235
    See related
    Ensembl:ENSG00000126803 MIM:140560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP70-2; HSP70-3
    Orthologs

    Genomic context

    See HSPA2 in Genome Data Viewer
    Location:
    14q23.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (64540741..64543237)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65007186..65009955)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene uncharacterized LOC102723809 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene protein phosphatase 1 regulatory subunit 36 Neighboring gene nucleoporin 50 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Nef nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
    Pr55(Gag) gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed
    gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
    Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock 70kDa protein 2 (HSPA2, HSP70-2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
    vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
    matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    glycolipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tau protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    male meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    male meiotic nuclear division TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of inclusion body assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium-transporting ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptonemal complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    CatSper complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    blood microparticle HDA PubMed 
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane HDA PubMed 
    nucleus HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heat shock-related 70 kDa protein 2
    Names
    epididymis secretory sperm binding protein
    heat shock 70kD protein 2
    heat shock 70kDa protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387931.1NP_001374860.1  heat shock-related 70 kDa protein 2

      Status: VALIDATED

      Source sequence(s)
      AL049869
    2. NM_021979.4NP_068814.2  heat shock-related 70 kDa protein 2

      See identical proteins and their annotated locations for NP_068814.2

      Status: VALIDATED

      Source sequence(s)
      BC001752, BC036107, CD300159, CN356507, DB042367
      Consensus CDS
      CCDS9766.1
      UniProtKB/Swiss-Prot
      P54652
      UniProtKB/TrEMBL
      A0A024R6B5
      Related
      ENSP00000247207.6, ENST00000247207.6
      Conserved Domains (1) summary
      PTZ00009
      Location:2615
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      64540741..64543237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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