U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tmem120b transmembrane protein 120B [ Mus musculus (house mouse) ]

    Gene ID: 330189, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tmem120bprovided by MGI
    Official Full Name
    transmembrane protein 120Bprovided by MGI
    Primary source
    MGI:MGI:3603158
    See related
    Ensembl:ENSMUSG00000054434 AllianceGenome:MGI:3603158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in fat cell differentiation and protein heterooligomerization. Located in nuclear inner membrane. Orthologous to human TMEM120B (transmembrane protein 120B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 36.3), mammary gland adult (RPKM 28.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tmem120b in Genome Data Viewer
    Location:
    5 F; 5 62.75 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123214329..123256272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123076265..123118213)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:123489053-123489354 Neighboring gene predicted gene, 42023 Neighboring gene MORN repeat containing 3 Neighboring gene STARR-seq mESC enhancer starr_14309 Neighboring gene STARR-positive B cell enhancer ABC_E6376 Neighboring gene predicted gene 6444 Neighboring gene STARR-seq mESC enhancer starr_14311 Neighboring gene STARR-seq mESC enhancer starr_14312 Neighboring gene STARR-positive B cell enhancer ABC_E10349 Neighboring gene STARR-positive B cell enhancer ABC_E4788 Neighboring gene STARR-positive B cell enhancer ABC_E6377 Neighboring gene STARR-positive B cell enhancer ABC_E1060 Neighboring gene ras homolog family member F (in filopodia) Neighboring gene STARR-positive B cell enhancer ABC_E8079 Neighboring gene STARR-seq mESC enhancer starr_14314 Neighboring gene expressed sequence AI480526 Neighboring gene STARR-positive B cell enhancer ABC_E2763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123591600-123591709 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599408-123599706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599709-123599818 Neighboring gene STARR-positive B cell enhancer ABC_E6378 Neighboring gene SET domain containing 1B Neighboring gene predicted gene, 54284

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039723.3NP_001034812.1  transmembrane protein 120B isoform 1

      See identical proteins and their annotated locations for NP_001034812.1

      Status: VALIDATED

      Source sequence(s)
      AC158114
      Consensus CDS
      CCDS39262.1
      UniProtKB/Swiss-Prot
      Q14BK6, Q3TA38, Q8R243
      Related
      ENSMUSP00000068551.9, ENSMUST00000067505.15
      Conserved Domains (1) summary
      pfam07851
      Location:9332
      TMPIT; TMPIT-like protein
    2. NM_001420280.1NP_001407209.1  transmembrane protein 120B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158114
      Related
      ENSMUSP00000107246.4, ENSMUST00000111619.10
    3. NM_001420281.1NP_001407210.1  transmembrane protein 120B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158114

    RNA

    1. NR_185159.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158114
    2. NR_185160.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158114

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123214329..123256272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784711.3 RNA Sequence

      Related
      ENSMUST00000161059.8