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    DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 [ Homo sapiens (human) ]

    Gene ID: 3301, updated on 21-Apr-2019

    Summary

    Official Symbol
    DNAJA1provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A1provided by HGNC
    Primary source
    HGNC:HGNC:5229
    See related
    Ensembl:ENSG00000086061 MIM:602837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSJ-2; HSPF4; NEDD7; hDJ-2
    Summary
    This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in testis (RPKM 94.7), brain (RPKM 86.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See DNAJA1 in Genome Data Viewer
    Location:
    9p21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (33025203..33039907)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33025209..33039905)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aprataxin Neighboring gene transcription elongation factor A protein 1 pseudogene Neighboring gene L antigen family member 3 pseudogene 1 Neighboring gene SMU1 DNA replication regulator and spliceosomal factor Neighboring gene beta-1,4-galactosyltransferase 1 Neighboring gene B4GALT1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of DnaJ (Hsp40) homolog, subfamily A, member 1 (DNAJA1) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev The expression of HSP40A1 (DNAJA1) inhibits HIV-1 Rev expression at the posttranscriptional levels, leading to the reduction of HIV-1 RNA accumulation PubMed
    Vif vif HIV-1 Vif interacts with DNAJA1; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed
    capsid gag HSP40A1 (DNAJA1) inhibits HIV-1 production as measured by the level of viral p24 capsid in the culture supernatant. The HSP40A1 (1-83) mutant lacking most of the C-terminal portion is more potent in inhibiting HIV-1 production than its wild-type PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    C3HC4-type RING finger domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Tat protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chaperone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    low-density lipoprotein particle receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasmic side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    membrane HDA PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily A member 1
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 1
    dnaJ protein homolog 2
    heat shock 40 kDa protein 4
    heat shock protein J2
    heat shock protein, DNAJ-like 2
    human DnaJ protein 2
    neural precursor cell expressed, developmentally down-regulated 7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001314039.1NP_001300968.1  dnaJ homolog subfamily A member 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK095541, AK298725, BM469197, BU508753, DA003255, DB575768
      UniProtKB/TrEMBL
      B7Z5C0
      Conserved Domains (1) summary
      cl28246
      Location:2237
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. NM_001539.4NP_001530.1  dnaJ homolog subfamily A member 1 isoform 1

      See identical proteins and their annotated locations for NP_001530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK095541, BC008182, BI462555, BU508753, DB575768
      Consensus CDS
      CCDS6533.1
      UniProtKB/Swiss-Prot
      P31689
      Related
      ENSP00000369127.3, ENST00000330899.5
      Conserved Domains (1) summary
      cl28246
      Location:2394
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      33025203..33039907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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