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    DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 [ Homo sapiens (human) ]

    Gene ID: 3300, updated on 7-Jul-2024

    Summary

    Official Symbol
    DNAJB2provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B2provided by HGNC
    Primary source
    HGNC:HGNC:5228
    See related
    Ensembl:ENSG00000135924 MIM:604139; AllianceGenome:HGNC:5228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSJ1; CMT2T; DSMA5; HMNR5; HSJ-1; HSPF3
    Summary
    This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
    Expression
    Ubiquitous expression in brain (RPKM 54.3), testis (RPKM 27.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DNAJB2 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219279366..219286895)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219764122..219771651)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220144088..220151617)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220109882-220110464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12351 Neighboring gene serine/threonine kinase 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17148 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220142208-220142912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220150891-220151858 Neighboring gene Sharpr-MPRA regulatory region 13803 Neighboring gene protein tyrosine phosphatase receptor type N Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17149 Neighboring gene microRNA 153-1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:220199445-220200644 Neighboring gene regulated endocrine specific protein 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 2 (DNAJB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpr vpr HIV-1 Vpr downregulates DNAJ protein homolog HSJ1 in PHA-stimulated PBMC PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-modified protein reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chaperone-mediated protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of inclusion body assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron cellular homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 2
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 2
    dnaJ protein homolog 1
    heat shock 40 kDa protein 3
    heat shock protein J1
    heat shock protein, neuronal DNAJ-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029553.1 RefSeqGene

      Range
      5049..12578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039550.2NP_001034639.1  dnaJ homolog subfamily B member 2 isoform a

      See identical proteins and their annotated locations for NP_001034639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform a.
      Source sequence(s)
      AC114803, BC047056
      Consensus CDS
      CCDS46519.1
      UniProtKB/TrEMBL
      C9JXB9
      Related
      ENSP00000375936.4, ENST00000392086.8
      Conserved Domains (1) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. NM_006736.6NP_006727.2  dnaJ homolog subfamily B member 2 isoform b

      See identical proteins and their annotated locations for NP_006727.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1. This results in a longer isoform (b) with a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC114803, BC047056, BF795662, BT007088, BX478051, CA392563
      Consensus CDS
      CCDS2439.1
      UniProtKB/Swiss-Prot
      A8K9P6, P25686, Q53QD7, Q8IUK1, Q8IUK2, Q96F52
      UniProtKB/TrEMBL
      A8K0R1
      Related
      ENSP00000338019.5, ENST00000336576.10
      Conserved Domains (1) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      219279366..219286895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219764122..219771651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)