parvin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: parvinprovided by FlyBase
Primary source: FLYBASE:FBgn0052528
Locus tag: Dmel_CG32528
See related: AllianceGenome:FB:FBgn0052528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12533; CG32528; Dmel\CG32528
Summary: Predicted to enable actin binding activity. Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces and muscle attachment. Located in focal adhesion. Is expressed in adult head; adult heart; embryonic dorsal epidermis; muscle system; and visceral mesoderm. Used to study cancer. Orthologous to several human genes including PARVA (parvin alpha) and PARVB (parvin beta). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19746041..19748458)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19640074..19642491)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Thus, distinct genetic interactions of Parvin occur in different cell types and second site modifier screens are required to uncover such genetic circuits
Title: Parvin overexpression uncovers tissue-specific genetic pathways and disrupts F-actin to induce apoptosis in the developing epithelia in Drosophila.
Parvin is localized at sites of integrin adhesion during embryogenesis.
Title: Functional analysis of parvin and different modes of IPP-complex assembly at integrin sites during Drosophila development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed