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    Dennd4c DENN/MADD domain containing 4C [ Mus musculus (house mouse) ]

    Gene ID: 329877, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dennd4cprovided by MGI
    Official Full Name
    DENN/MADD domain containing 4Cprovided by MGI
    Primary source
    MGI:MGI:1914769
    See related
    Ensembl:ENSMUSG00000038024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA420392; 1700065A05Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.8), subcutaneous fat pad adult (RPKM 4.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dennd4c in Genome Data Viewer
    Location:
    4; 4 C4
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86666761..86768840)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86748518..86850603)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (86394459..86476071)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene perilipin 2 pseudogene Neighboring gene perilipin 2 Neighboring gene predicted gene, 42312 Neighboring gene predicted gene 6521 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ribosomal protein S6 Neighboring gene alkaline ceramidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in insulin-responsive compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of retromer complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DENN domain-containing protein 4C
    Names
    likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_184088.1NP_908976.1  DENN domain-containing protein 4C

      See identical proteins and their annotated locations for NP_908976.1

      Status: VALIDATED

      Source sequence(s)
      AL772228, BC146602, BX005084
      Consensus CDS
      CCDS51218.2
      UniProtKB/Swiss-Prot
      A6H8H2
      Conserved Domains (4) summary
      smart00801
      Location:558631
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192275
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308491
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      86666761..86768840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538022.4XP_006538085.1  DENN domain-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_006538085.1

      UniProtKB/Swiss-Prot
      A6H8H2
      Related
      ENSMUSP00000080685.7, ENSMUST00000082026.14
      Conserved Domains (4) summary
      smart00801
      Location:558631
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192275
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308491
      DENN; DENN (AEX-3) domain
    2. XM_006538023.4XP_006538086.1  DENN domain-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_006538086.1

      UniProtKB/Swiss-Prot
      A6H8H2
      Conserved Domains (4) summary
      smart00801
      Location:558631
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192275
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308491
      DENN; DENN (AEX-3) domain
    3. XM_036164193.1XP_036020086.1  DENN domain-containing protein 4C isoform X2

      Related
      ENSMUSP00000123367.3, ENSMUST00000142837.3
      Conserved Domains (4) summary
      smart00801
      Location:558631
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192275
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308491
      DENN; DENN (AEX-3) domain
    4. XM_006538024.4XP_006538087.1  DENN domain-containing protein 4C isoform X3

      Conserved Domains (4) summary
      smart00801
      Location:323396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:584613
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:73256
      DENN; DENN (AEX-3) domain
      cl04085
      Location:140
      uDENN; uDENN domain
    5. XM_006538025.4XP_006538088.1  DENN domain-containing protein 4C isoform X4

    RNA

    1. XR_390327.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081014.1: Suppressed sequence

      Description
      NM_001081014.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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