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    Ctdspl2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 [ Mus musculus (house mouse) ]

    Gene ID: 329506, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ctdspl2provided by MGI
    Official Full Name
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2provided by MGI
    Primary source
    MGI:MGI:1196405
    See related
    Ensembl:ENSMUSG00000033411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCP4; D2Ertd485e
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.0), CNS E11.5 (RPKM 6.7) and 24 other tissues See more
    Orthologs

    Genomic context

    See Ctdspl2 in Genome Data Viewer
    Location:
    2 E5; 2 60.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (121956001..122015326)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121782189..121839322)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cancer susceptibility candidate 4 Neighboring gene predicted gene, 39916 Neighboring gene melanoma antigen, family B, 3 Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene beta-2 microglobulin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CTD small phosphatase-like protein 2
    Names
    CTDSP-like 2
    NP_001277920.1
    NP_001277921.1
    NP_997615.1
    XP_006499839.1
    XP_011237929.1
    XP_017174542.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290991.1NP_001277920.1  CTD small phosphatase-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001277920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
      Source sequence(s)
      AK039162, AK053513, AK163262, BB183048
      Consensus CDS
      CCDS71130.1
      UniProtKB/Swiss-Prot
      Q8BG15
      Related
      ENSMUSP00000106207.1, ENSMUST00000110578.7
      Conserved Domains (1) summary
      TIGR02251
      Location:285446
      HIF-SF_euk; Dullard-like phosphatase domain
    2. NM_001290992.1NP_001277921.1  CTD small phosphatase-like protein 2 isoform c

      See identical proteins and their annotated locations for NP_001277921.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK033382, AK039162, AK163262, BB183048
      UniProtKB/Swiss-Prot
      Q8BG15
      Conserved Domains (1) summary
      TIGR02251
      Location:172327
      HIF-SF_euk; Dullard-like phosphatase domain
    3. NM_212450.4NP_997615.1  CTD small phosphatase-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_997615.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK033382, AK039162, AK163262, BB183048
      Consensus CDS
      CCDS16652.1
      UniProtKB/Swiss-Prot
      Q8BG15
      Related
      ENSMUSP00000047543.6, ENSMUST00000036647.12
      Conserved Domains (1) summary
      TIGR02251
      Location:286447
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      121956001..122015326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499776.2XP_006499839.1  CTD small phosphatase-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499839.1

      Conserved Domains (1) summary
      cl21460
      Location:286322
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. XM_017319053.1XP_017174542.1  CTD small phosphatase-like protein 2 isoform X1

      Conserved Domains (1) summary
      cl21460
      Location:286322
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    3. XM_011239627.2XP_011237929.1  CTD small phosphatase-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011237929.1

      Conserved Domains (1) summary
      cl21460
      Location:286322
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. XR_001783138.1 RNA Sequence

    2. XR_374482.1 RNA Sequence

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