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    Pla2g4e phospholipase A2, group IVE [ Mus musculus (house mouse) ]

    Gene ID: 329502, updated on 22-Aug-2021

    Summary

    Official Symbol
    Pla2g4eprovided by MGI
    Official Full Name
    phospholipase A2, group IVEprovided by MGI
    Primary source
    MGI:MGI:1919144
    See related
    Ensembl:ENSMUSG00000050211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pl; C230096D22; Pla2epsilon; 2310026J01Rik
    Expression
    Biased expression in CNS E18 (RPKM 3.5), cortex adult (RPKM 3.4) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Pla2g4e in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119996893..120077306, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120166412..120245630, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119992148..120071071, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 28042 Neighboring gene phospholipase A2, group IVB (cytosolic) Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4 Neighboring gene predicted gene, 52575 Neighboring gene predicted gene, 52560 Neighboring gene phospholipase A2, group IVD Neighboring gene phospholipase A2, group IVF

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytosolic phospholipase A2 epsilon
    Names
    cPLA2-epsilon
    calcium-dependent N-acyltransferase
    phospholipase A2, group 4E
    NP_001350019.1
    NP_001350020.1
    NP_808513.2
    XP_006499833.2
    XP_006499834.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363090.1NP_001350019.1  cytosolic phospholipase A2 epsilon isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL833774, AL844608, BX000525
      Conserved Domains (2) summary
      cl11396
      Location:239781
      Patatin_and_cPLA2; Patatins and Phospholipases
      cl14603
      Location:1101
      C2; C2 domain
    2. NM_001363091.1NP_001350020.1  cytosolic phospholipase A2 epsilon isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL833774, AL844608, BC066085
      Conserved Domains (1) summary
      cl11396
      Location:6497
      Patatin_and_cPLA2; Patatins and Phospholipases
    3. NM_001395470.1NP_001382399.1  cytosolic phospholipase A2 epsilon

      Status: VALIDATED

      Source sequence(s)
      AL833774, AL844608, BX000525
    4. NM_177845.4NP_808513.2  cytosolic phospholipase A2 epsilon isoform 1

      See identical proteins and their annotated locations for NP_808513.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB195277, AL833774, AL844608
      Consensus CDS
      CCDS16616.1
      UniProtKB/Swiss-Prot
      Q50L42
      Related
      ENSMUSP00000087525.5, ENSMUST00000090071.5
      Conserved Domains (3) summary
      cd07201
      Location:328870
      cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:82190
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:324811
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119996893..120077306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499771.5XP_006499834.1  cytosolic phospholipase A2 epsilon isoform X2

      Conserved Domains (3) summary
      cd07201
      Location:284826
      cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:38146
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:178285
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    2. XM_006499770.5XP_006499833.2  cytosolic phospholipase A2 epsilon isoform X1

      Conserved Domains (3) summary
      cd07201
      Location:261803
      cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:15123
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam18695
      Location:155262
      cPLA2_C2; Cytosolic phospholipases A2 C2-domain
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