Format

Send to:

Choose Destination
    • Showing Current items.

    Mcc mutated in colorectal cancers [ Mus musculus (house mouse) ]

    Gene ID: 328949, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mccprovided by MGI
    Official Full Name
    mutated in colorectal cancersprovided by MGI
    Primary source
    MGI:MGI:96930
    See related
    Ensembl:ENSMUSG00000071856 Vega:OTTMUSG00000055565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E330037C19; D18Ertd451e
    Expression
    Ubiquitous expression in lung adult (RPKM 10.4), cerebellum adult (RPKM 5.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Mcc in Genome Data Viewer
    Location:
    18 B3; 18 23.74 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (44425060..44812182, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (44584714..44971836, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene myotilin Neighboring gene decapping mRNA 2 Neighboring gene RIKEN cDNA A930012L18 gene Neighboring gene YTH domain containing 2 Neighboring gene predicted gene, 31706 Neighboring gene mortality factor 4 like 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    colorectal mutant cancer protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085373.1NP_001078842.1  colorectal mutant cancer protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC137150, AC147551, AK054528, AK158266, BU756994
      Consensus CDS
      CCDS50277.1
      UniProtKB/TrEMBL
      E9PWI3, Q3TYX4
      Related
      ENSMUSP00000087318.5, OTTMUSP00000072414, ENSMUST00000089874.8, OTTMUST00000137522
      Conserved Domains (4) summary
      cd00051
      Location:2480
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam10506
      Location:577640
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
      pfam13499
      Location:2578
      EF-hand_7; EF-hand domain pair
      pfam16046
      Location:146271
      FAM76; FAM76 protein
    2. NM_001085374.1NP_001078843.1  colorectal mutant cancer protein isoform 2

      See identical proteins and their annotated locations for NP_001078843.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC147551, AK054528, BU756994
      Consensus CDS
      CCDS50276.1
      UniProtKB/TrEMBL
      G3UW40
      Related
      ENSMUSP00000128032.1, OTTMUSP00000072415, ENSMUST00000164666.5, OTTMUST00000137523
      Conserved Domains (2) summary
      pfam10506
      Location:402465
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
      cl23720
      Location:13134
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      44425060..44812182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526024.3XP_006526087.1  colorectal mutant cancer protein isoform X2

      See identical proteins and their annotated locations for XP_006526087.1

      Conserved Domains (1) summary
      pfam10506
      Location:339402
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    2. XM_006526026.3XP_006526089.1  colorectal mutant cancer protein isoform X2

      See identical proteins and their annotated locations for XP_006526089.1

      Conserved Domains (1) summary
      pfam10506
      Location:339402
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    3. XM_006526025.3XP_006526088.1  colorectal mutant cancer protein isoform X2

      See identical proteins and their annotated locations for XP_006526088.1

      Conserved Domains (1) summary
      pfam10506
      Location:339402
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    4. XM_006526023.3XP_006526086.1  colorectal mutant cancer protein isoform X1

      Conserved Domains (1) summary
      pfam10506
      Location:431494
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033406.1: Suppressed sequence

      Description
      NM_001033406.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Support Center