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    upd1 unpaired 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32813, updated on 5-Jan-2023

    Summary

    Official Symbol
    upd1provided by FlyBase
    Official Full Name
    unpaired 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004956
    Locus tag
    Dmel_CG5993
    See related
    AllianceGenome:FB:FBgn0004956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5993; Dmel\CG5993; l(1)YC43; l(1)YM55; od; odsy; os; Os; OS; sis-c; sis-C; sisC; sy; unp; Unpaireds; upa; upd; Upd; UPD; Upd1; UPD1
    Summary
    Enables cytokine activity and extracellular matrix binding activity. Involved in several processes, including epithelial cell development; morphogenesis of an epithelium; and tube morphogenesis. Located in apical part of cell and extracellular space. Is expressed in several structures, including brain; dorsal closure embryo; gonad; gut section; and imaginal disc. Used to study congenital leptin deficiency. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See upd1 in Genome Data Viewer
    Location:
    17A5-17A5; 1-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18305354..18309291, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18199387..18203324, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene unpaired 3 Neighboring gene long non-coding RNA:CR15061 Neighboring gene long non-coding RNA:CR45608 Neighboring gene long non-coding RNA:CR45609

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apical constriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blastoderm segmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in embryonic development via the syncytial blastoderm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye-antennal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ-line stem-cell niche homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intestinal epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male germ-line stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in male germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mediolateral intercalation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of innate immune response HMP PubMed 
    involved_in paracrine signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in primary sex determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of embryonic cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sex determination, establishment of X:A ratio NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wing disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    unpaired 1
    Names
    CG5993-PA
    CG5993-PB
    CG5993-PC
    Unpaired/Out-stretched
    outstretched
    outstretched small eye
    outstretched-smalleye
    sisterless c
    small-eye
    unpaired
    unpaired1
    upd homolog
    upd1-PA
    upd1-PB
    upd1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18305354..18309291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298473.1NP_001285402.1  unpaired 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285402.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWW4
      Related
      FBpp0310189, FBtr0343592
      Conserved Domains (1) summary
      pfam15972
      Location:71333
      Unpaired; Unpaired protein
    2. NM_001103545.3NP_001097015.1  unpaired 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWW4
      Related
      FBpp0111760, FBtr0112847
      Conserved Domains (1) summary
      pfam15972
      Location:71333
      Unpaired; Unpaired protein
    3. NM_080356.4NP_525095.2  unpaired 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525095.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWW4
      Related
      FBpp0074353, FBtr0074581
      Conserved Domains (1) summary
      pfam15972
      Location:71333
      Unpaired; Unpaired protein