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    Togaram1 TOG array regulator of axonemal microtubules 1 [ Mus musculus (house mouse) ]

    Gene ID: 328108, updated on 23-Jun-2021

    Summary

    Official Symbol
    Togaram1provided by MGI
    Official Full Name
    TOG array regulator of axonemal microtubules 1provided by MGI
    Primary source
    MGI:MGI:2684313
    See related
    Ensembl:ENSMUSG00000035614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam179; Fam179b; BC062107; C130034K06; A430041B07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 5.8), frontal lobe adult (RPKM 3.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Togaram1 in Genome Data Viewer
    Location:
    12; 12 C1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (65012350..65069347)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (64965576..65022573)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (66066729..66123560)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 1 Neighboring gene predicted gene, 51965 Neighboring gene predicted gene 527 Neighboring gene kelch-like 28 Neighboring gene predicted gene, 51966 Neighboring gene pre-mRNA processing factor 39 Neighboring gene predicted gene, 25970

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0423, MGC189816, MGC189944, mKIAA0423

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    TOG array regulator of axonemal microtubules protein 1
    Names
    crescerin-1
    family with sequence similarity 179, member B
    protein FAM179B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364325.1NP_001351254.1  TOG array regulator of axonemal microtubules protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159621, AC159632
      Consensus CDS
      CCDS88345.1
      Related
      ENSMUSP00000152616.2, ENSMUST00000223166.2
      Conserved Domains (2) summary
      sd00044
      Location:395419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:789905
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    2. NM_177805.3NP_808473.2  TOG array regulator of axonemal microtubules protein 1 isoform 2

      See identical proteins and their annotated locations for NP_808473.2

      Status: VALIDATED

      Source sequence(s)
      AC159621, AC159632
      Consensus CDS
      CCDS49075.1
      UniProtKB/Swiss-Prot
      Q6A070
      Related
      ENSMUSP00000070382.8, ENSMUST00000066296.9
      Conserved Domains (2) summary
      pfam08192
      Location:9571108
      Peptidase_S64; Peptidase family S64
      sd00044
      Location:395419
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      65012350..65069347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516020.4XP_006516083.1  TOG array regulator of axonemal microtubules protein 1 isoform X1

      Conserved Domains (2) summary
      sd00044
      Location:395419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    2. XM_006516022.4XP_006516085.1  TOG array regulator of axonemal microtubules protein 1 isoform X2

      Conserved Domains (2) summary
      sd00044
      Location:395419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    3. XM_036157506.1XP_036013399.1  TOG array regulator of axonemal microtubules protein 1 isoform X3

      Conserved Domains (2) summary
      sd00044
      Location:395419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    4. XM_006516023.4XP_006516086.1  TOG array regulator of axonemal microtubules protein 1 isoform X4

      Conserved Domains (2) summary
      sd00044
      Location:395419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    5. XM_017315119.2XP_017170608.1  TOG array regulator of axonemal microtubules protein 1 isoform X5

      Conserved Domains (2) summary
      sd00044
      Location:395419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    RNA

    1. XR_004937521.1 RNA Sequence

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