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    Frs2 fibroblast growth factor receptor substrate 2 [ Mus musculus (house mouse) ]

    Gene ID: 327826, updated on 24-Aug-2021

    Summary

    Official Symbol
    Frs2provided by MGI
    Official Full Name
    fibroblast growth factor receptor substrate 2provided by MGI
    Primary source
    MGI:MGI:1100860
    See related
    Ensembl:ENSMUSG00000020170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SN; Frs; SNT1; Frs2alpha; 4732458E18; C330018A15Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.1), CNS E14 (RPKM 10.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Frs2 in Genome Data Viewer
    Location:
    10; 10 D2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116905330..116984442, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117070127..117148474, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (116507183..116585530, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 10 Neighboring gene chaperonin containing Tcp1, subunit 2 (beta) Neighboring gene predicted gene, 40811 Neighboring gene predicted gene, 53635 Neighboring gene RIKEN cDNA 4930423D24 gene Neighboring gene predicted gene, 40769

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens placode formation involved in camera-type eye formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fibroblast growth factor receptor substrate 2
    Names
    FGFR substrate 2
    FGFR-signaling adaptor SNT
    FRS2-alpha
    SNT-1
    suc1-associated neurotrophic factor target 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177798.3NP_808466.1  fibroblast growth factor receptor substrate 2

      See identical proteins and their annotated locations for NP_808466.1

      Status: PROVISIONAL

      Source sequence(s)
      BC043109
      Consensus CDS
      CCDS24190.1
      UniProtKB/Swiss-Prot
      Q8C180
      Related
      ENSMUSP00000020381.4, ENSMUST00000020381.5
      Conserved Domains (1) summary
      cd01202
      Location:15106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      116905330..116984442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155852.1XP_036011745.1  fibroblast growth factor receptor substrate 2 isoform X2

      Conserved Domains (1) summary
      cd01202
      Location:15106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    2. XM_036155854.1XP_036011747.1  fibroblast growth factor receptor substrate 2 isoform X2

      Conserved Domains (1) summary
      cd01202
      Location:15106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    3. XM_036155856.1XP_036011749.1  fibroblast growth factor receptor substrate 2 isoform X3

      Conserved Domains (1) summary
      cd01202
      Location:169
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    4. XM_036155851.1XP_036011744.1  fibroblast growth factor receptor substrate 2 isoform X1

      Conserved Domains (1) summary
      cd01202
      Location:24115
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    5. XM_036155855.1XP_036011748.1  fibroblast growth factor receptor substrate 2 isoform X3

      Conserved Domains (1) summary
      cd01202
      Location:169
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    6. XM_036155853.1XP_036011746.1  fibroblast growth factor receptor substrate 2 isoform X2

      Conserved Domains (1) summary
      cd01202
      Location:15106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
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