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    Dna2 DNA replication helicase/nuclease 2 [ Mus musculus (house mouse) ]

    Gene ID: 327762, updated on 19-Mar-2019

    Summary

    Official Symbol
    Dna2provided by MGI
    Official Full Name
    DNA replication helicase/nuclease 2provided by MGI
    Primary source
    MGI:MGI:2443732
    See related
    Ensembl:ENSMUSG00000036875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dna2l; E130315B21Rik
    Expression
    Broad expression in liver E14 (RPKM 14.4), liver E14.5 (RPKM 13.2) and 18 other tissues See more
    Orthologs

    Genomic context

    See Dna2 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (62946978..62974188)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62409777..62436936)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0083

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    5'-3' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    5'-flap endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    5'-flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    site-specific endodeoxyribonuclease activity, specific for altered base ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA double-strand break processing ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication, Okazaki fragment processing ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication, removal of RNA primer ISO
    Inferred from Sequence Orthology
    more info
     
    base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic telomere maintenance via semi-conservative replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleic acid phosphodiester bond hydrolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork reversal IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with gamma DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA replication ATP-dependent helicase/nuclease DNA2
    Names
    DNA replication ATP-dependent helicase-like homolog
    DNA replication helicase 2 homolog
    DNA2-like helicase
    NP_796346.2
    XP_017169460.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177372.3NP_796346.2  DNA replication ATP-dependent helicase/nuclease DNA2

      See identical proteins and their annotated locations for NP_796346.2

      Status: VALIDATED

      Source sequence(s)
      AK028381, AK053856, BM202919, BY768981, CO433698
      Consensus CDS
      CCDS35923.1
      UniProtKB/Swiss-Prot
      Q6ZQJ5
      Related
      ENSMUSP00000115750.1, ENSMUST00000131422.7
      Conserved Domains (5) summary
      TIGR00376
      Location:4721034
      TIGR00376; DNA helicase, putative
      pfam08696
      Location:72283
      Dna2; DNA replication factor Dna2
      pfam13087
      Location:8061020
      AAA_12; AAA domain
      cl00641
      Location:256398
      Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
      cl21455
      Location:626830
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_152862.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA407737, AK028381, AK053856, BY768981, CO433698

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      62946978..62974188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313971.1XP_017169460.1  DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1

      Related
      ENSMUSP00000090119.5, ENSMUST00000092462.11
      Conserved Domains (5) summary
      pfam08696
      Location:72283
      Dna2; DNA replication factor Dna2
      pfam13086
      Location:626799
      AAA_11; AAA domain
      cl00641
      Location:256398
      Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
      cl21455
      Location:626830
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl22977
      Location:806935
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RNA

    1. XR_380406.3 RNA Sequence

    2. XR_380405.3 RNA Sequence

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