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    SERPINA9 serpin family A member 9 [ Homo sapiens (human) ]

    Gene ID: 327657, updated on 17-Jun-2024

    Summary

    Official Symbol
    SERPINA9provided by HGNC
    Official Full Name
    serpin family A member 9provided by HGNC
    Primary source
    HGNC:HGNC:15995
    See related
    Ensembl:ENSG00000170054 MIM:615677; AllianceGenome:HGNC:15995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCET1; SERPINA11; SERPINA11b
    Summary
    Enables serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in cytoplasm and membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lymph node (RPKM 11.5) and appendix (RPKM 4.1) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SERPINA9 in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94462721..94476197, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88692234..88705726, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94929058..94942534, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene serpin family A member 11 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94917415-94918091 Neighboring gene uncharacterized LOC105370635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94939998-94940750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94951885-94952418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94952419-94952950 Neighboring gene Sharpr-MPRA regulatory region 8049 Neighboring gene serpin family A member 12 Neighboring gene uncharacterized LOC124903410

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC131906

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serpin A9
    Names
    centerin
    germinal center B-cell-expressed transcript 1 protein
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
    serine proteinase inhibitor A11
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042518.2NP_001035983.2  serpin A9 isoform B precursor

      Status: VALIDATED

      Source sequence(s)
      AL132708
      Consensus CDS
      CCDS41983.2
      UniProtKB/TrEMBL
      A0A6Q8JH89
      Related
      ENSP00000298845.8, ENST00000298845.12
    2. NM_001284275.2NP_001271204.2  serpin A9 isoform C

      Status: VALIDATED

      Source sequence(s)
      AL132708
      Consensus CDS
      CCDS91925.1
      UniProtKB/TrEMBL
      A0A6Q8LYX2
      Related
      ENSP00000414092.2, ENST00000448305.6
    3. NM_001284276.2NP_001271205.1  serpin A9 isoform D

      Status: VALIDATED

      Source sequence(s)
      AL132708
      Consensus CDS
      CCDS61542.1
      UniProtKB/Swiss-Prot
      Q86WD7
      Related
      ENSP00000409012.2, ENST00000424550.6
      Conserved Domains (1) summary
      cl00137
      Location:1280
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    4. NM_175739.4NP_783866.3  serpin A9 isoform A precursor

      Status: VALIDATED

      Source sequence(s)
      AL132708
      Consensus CDS
      CCDS41982.2
      UniProtKB/Swiss-Prot
      B4DVH4, B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86WD7, Q86YP6, Q86YP7
      Related
      ENSP00000501517.1, ENST00000674397.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      94462721..94476197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536715.3XP_011535017.1  serpin A9 isoform X1

      See identical proteins and their annotated locations for XP_011535017.1

      UniProtKB/Swiss-Prot
      B4DVH4, B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86WD7, Q86YP6, Q86YP7
      Conserved Domains (1) summary
      cd02056
      Location:48411
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
    2. XM_047431341.1XP_047287297.1  serpin A9 isoform X2

      UniProtKB/TrEMBL
      A0A6Q8LYX2
    3. XM_047431339.1XP_047287295.1  serpin A9 isoform X1

      UniProtKB/Swiss-Prot
      B4DVH4, B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86WD7, Q86YP6, Q86YP7
    4. XM_011536716.3XP_011535018.1  serpin A9 isoform X2

      See identical proteins and their annotated locations for XP_011535018.1

      UniProtKB/TrEMBL
      A0A6Q8LYX2
      Conserved Domains (1) summary
      cl00137
      Location:1331
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    5. XM_011536714.3XP_011535016.1  serpin A9 isoform X1

      See identical proteins and their annotated locations for XP_011535016.1

      UniProtKB/Swiss-Prot
      B4DVH4, B9ZVX3, Q2T9J2, Q6UWP9, Q86WD4, Q86WD5, Q86WD6, Q86WD7, Q86YP6, Q86YP7
      Related
      ENSP00000369723.3, ENST00000380365.7
      Conserved Domains (1) summary
      cd02056
      Location:48411
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      88692234..88705726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375977.1XP_054231952.1  serpin A9 isoform X2

      UniProtKB/TrEMBL
      A0A6Q8LYX2
    2. XM_054375975.1XP_054231950.1  serpin A9 isoform X1

    3. XM_054375976.1XP_054231951.1  serpin A9 isoform X1

    4. XM_054375978.1XP_054231953.1  serpin A9 isoform X2

      UniProtKB/TrEMBL
      A0A6Q8LYX2
    5. XM_054375974.1XP_054231949.1  serpin A9 isoform X1