hdac10 histone deacetylase 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hdac10provided by ZNC
Official Full Name: histone deacetylase 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5464
See related: Ensembl:ENSDARG00000086458 AllianceGenome:ZFIN:ZDB-GENE-030131-5464
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55652; wu:fd19e10
Summary: Enables acetylspermidine deacetylase activity and zinc ion binding activity. Acts upstream of or within regulation of tubulin deacetylation; spermidine deacetylation; and swimming behavior. Predicted to be located in cytoplasm. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (5015035..5033064)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (4888456..4906636)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10.
Title: X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10.
The binding of ketonic substrate analogues to HDAC10 is identical to the chemistry involved in the first step of catalysis, i.e., nucleophilic attack of a Zn(2+)-bound water molecule at the scissile carbonyl group of N(8)-acetylspermidine.
Title: Binding of N(8)-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation.
HDAC10 structure and molecular function as a polyamine deacetylase has been reported.
Title: Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetylputrescine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables acetylspermidine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylspermidine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
NOT enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within polyamine deacetylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of tubulin deacetylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spermidine deacetylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within swimming behavior	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polyamine deacetylase HDAC10

NP_956069.1

EC 3.5.1.48

EC 3.5.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199775.1 → NP_956069.1 polyamine deacetylase HDAC10

See identical proteins and their annotated locations for NP_956069.1

Status: PROVISIONAL

Source sequence(s)

BC044446

UniProtKB/Swiss-Prot

F1QCV2, Q803K0

Related

ENSDARP00000109870.2, ENSDART00000127600.4

Conserved Domains (2) summary

cd11683
Location:20 → 356

HDAC10; Histone deacetylase 10

cl17011
Location:559 → 665

Arginase_HDAC; Arginase-like and histone-like hydrolases