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    Upf2 UPF2 regulator of nonsense transcripts homolog (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 326622, updated on 12-Apr-2023

    Summary

    Official Symbol
    Upf2provided by MGI
    Official Full Name
    UPF2 regulator of nonsense transcripts homolog (yeast)provided by MGI
    Primary source
    MGI:MGI:2449307
    See related
    Ensembl:ENSMUSG00000043241 AllianceGenome:MGI:2449307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable telomeric DNA binding activity. Acts upstream of or within animal organ regeneration and liver development. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; cytosol; and perinuclear region of cytoplasm. Predicted to be part of exon-exon junction complex and polysome. Predicted to be active in cytoplasm. Is expressed in several structures, including heart; liver; lung; spleen; and testis. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.1), bladder adult (RPKM 4.3) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Upf2 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_04 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5956218..6061514)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5951447..6056703)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene predicted gene 13267 Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene predicted gene, 30136 Neighboring gene proline and serine rich 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of polysome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of nonsense transcripts 2
    Names
    nonsense mRNA reducing factor 2
    up-frameshift suppressor 2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081132.1NP_001074601.1  regulator of nonsense transcripts 2

      See identical proteins and their annotated locations for NP_001074601.1

      Status: PROVISIONAL

      Source sequence(s)
      AL928735, AL928924, CR388026
      Consensus CDS
      CCDS38041.1
      UniProtKB/Swiss-Prot
      A2AT37
      UniProtKB/TrEMBL
      A2AT37
      Related
      ENSMUSP00000058375.7, ENSMUST00000060092.13
      Conserved Domains (4) summary
      smart00543
      Location:569756
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:774984
      MIF4G; MIF4G domain
      pfam04050
      Location:10911215
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357420
      DUF1451; Zinc-ribbon containing domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      5956218..6061514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497486.2XP_006497549.1  regulator of nonsense transcripts 2 isoform X2

      See identical proteins and their annotated locations for XP_006497549.1

      Conserved Domains (3) summary
      smart00543
      Location:771984
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam04050
      Location:10861214
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357420
      DUF1451; Zinc-ribbon containing domain
    2. XM_006497487.2XP_006497550.1  regulator of nonsense transcripts 2 isoform X3

      Conserved Domains (3) summary
      smart00543
      Location:771984
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam04050
      Location:10861215
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357420
      DUF1451; Zinc-ribbon containing domain
    3. XM_006497488.5XP_006497551.1  regulator of nonsense transcripts 2 isoform X4

      Conserved Domains (2) summary
      smart00543
      Location:167362
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      cl19727
      Location:357420
      DUF1451; Zinc-ribbon containing domain
    4. XM_006497485.5XP_006497548.1  regulator of nonsense transcripts 2 isoform X1

      See identical proteins and their annotated locations for XP_006497548.1

      UniProtKB/Swiss-Prot
      A2AT37
      UniProtKB/TrEMBL
      A2AT37
      Conserved Domains (4) summary
      smart00543
      Location:569756
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:774984
      MIF4G; MIF4G domain
      pfam04050
      Location:10911215
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357420
      DUF1451; Zinc-ribbon containing domain

    RNA

    1. XR_001783050.2 RNA Sequence