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    HPGD 15-hydroxyprostaglandin dehydrogenase [ Homo sapiens (human) ]

    Gene ID: 3248, updated on 8-Jul-2021

    Summary

    Official Symbol
    HPGDprovided by HGNC
    Official Full Name
    15-hydroxyprostaglandin dehydrogenaseprovided by HGNC
    Primary source
    HGNC:HGNC:5154
    See related
    Ensembl:ENSG00000164120 MIM:601688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1
    Summary
    This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
    Expression
    Biased expression in urinary bladder (RPKM 176.8), stomach (RPKM 67.9) and 11 other tissues See more
    Orthologs
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    Genomic context

    See HPGD in Genome Data Viewer
    Location:
    4q34.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (174490175..174522893, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (175411326..175444044, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 4276 Neighboring gene Sharpr-MPRA regulatory region 9212 Neighboring gene uncharacterized LOC105377548 Neighboring gene zinc finger protein 772 pseudogene Neighboring gene uncharacterized LOC105377549

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in ductus arteriosus closure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in female pregnancy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipoxygenase pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ovulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in parturition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in prostaglandin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of prostaglandin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thrombin-activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
    Names
    15-hydroxyprostaglandin dehydrogenase (NAD(+))
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
    hydroxyprostaglandin dehydrogenase 15-(NAD)
    prostaglandin dehydrogenase 1
    short chain dehydrogenase/reductase family 36C member 1
    NP_000851.2
    NP_001139288.1
    NP_001243230.1
    NP_001243234.1
    NP_001243235.1
    NP_001243236.1
    NP_001350503.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011689.1 RefSeqGene

      Range
      5154..37467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000860.6NP_000851.2  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1

      See identical proteins and their annotated locations for NP_000851.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC096751, AI435471, BC018986, DC420578
      Consensus CDS
      CCDS3821.1
      UniProtKB/Swiss-Prot
      P15428
      Related
      ENSP00000296522.6, ENST00000296522.11
      Conserved Domains (1) summary
      cd05323
      Location:6254
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
    2. NM_001145816.3NP_001139288.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2

      See identical proteins and their annotated locations for NP_001139288.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096751, AI435471, AK300940, BC018986, DC420578, X82460
      Consensus CDS
      CCDS54821.1
      UniProtKB/Swiss-Prot
      P15428
      Related
      ENSP00000296521.7, ENST00000296521.11
      Conserved Domains (1) summary
      cd05323
      Location:6168
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
    3. NM_001256301.1NP_001243230.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3

      See identical proteins and their annotated locations for NP_001243230.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences result in translation at a downstream start codon and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 6 encode the same protein (isoform 3).
      Source sequence(s)
      AI435471, AK296642, BC018986
      Consensus CDS
      CCDS58933.1
      UniProtKB/Swiss-Prot
      P15428
      Related
      ENSP00000422418.1, ENST00000510901.5
      Conserved Domains (1) summary
      cl21454
      Location:1133
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_001256305.2NP_001243234.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4

      See identical proteins and their annotated locations for NP_001243234.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the 3' coding region, which results in a frameshift and early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and contains a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096751, AI435471, AK058013, BC018986, DC420578, U63296
      Consensus CDS
      CCDS58935.1
      UniProtKB/Swiss-Prot
      P15428
      Related
      ENSP00000443644.1, ENST00000542498.5
      Conserved Domains (1) summary
      cl25409
      Location:6143
      SDR; Short-chain dehydrogenases/reductases (SDR)
    5. NM_001256306.2NP_001243235.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5

      See identical proteins and their annotated locations for NP_001243235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. It encodes isoform 5, which is shorter but contains the same N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC096751, AI435471, AK300125, BC018986
      Consensus CDS
      CCDS58934.1
      UniProtKB/Swiss-Prot
      P15428
      Related
      ENSP00000398720.2, ENST00000422112.6
      Conserved Domains (1) summary
      cl25409
      Location:6186
      SDR; Short-chain dehydrogenases/reductases (SDR)
    6. NM_001256307.2NP_001243236.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3

      See identical proteins and their annotated locations for NP_001243236.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, to encode an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 6 encode the same protein (isoform 3).
      Source sequence(s)
      AC096751, AI435471, AK300524, BC018986
      Consensus CDS
      CCDS58933.1
      UniProtKB/Swiss-Prot
      P15428
      Related
      ENSP00000438017.1, ENST00000541923.5
      Conserved Domains (1) summary
      cl21454
      Location:1133
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    7. NM_001363574.2NP_001350503.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC096751, BX396257
      Consensus CDS
      CCDS87280.1
      Related
      ENSP00000420892.1, ENST00000504433.1
      Conserved Domains (1) summary
      cl25409
      Location:6141
      SDR; Short-chain dehydrogenases/reductases (SDR)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      174490175..174522893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_938728.2 RNA Sequence

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