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    Xpnpep3 X-prolyl aminopeptidase 3, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 321003, updated on 12-Aug-2018

    Summary

    Official Symbol
    Xpnpep3provided by MGI
    Official Full Name
    X-prolyl aminopeptidase 3, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:2445217
    See related
    Ensembl:ENSMUSG00000022401 Vega:OTTMUSG00000035640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APP3; E430012M05Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 3.3), placenta adult (RPKM 2.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Xpnpep3 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (81400132..81457476)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (81230618..81285318)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 Neighboring gene suppression of tumorigenicity 13 Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene predicted gene 17025 Neighboring gene ring-box 1 Neighboring gene 60S ribosomal protein L29 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    xaa-Pro aminopeptidase 3; probable Xaa-Pro aminopeptidase 3
    Names
    X-Pro aminopeptidase 3
    aminopeptidase P3
    NP_796284.1
    XP_006521149.1
    XP_006521150.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347075.1NP_001334004.1  xaa-Pro aminopeptidase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109153, AK035269, BB663087, CK635306, EH097540
      Consensus CDS
      CCDS84182.1
      UniProtKB/Swiss-Prot
      B7ZMP1
    2. NM_177310.3NP_796284.1  xaa-Pro aminopeptidase 3 isoform 1

      See identical proteins and their annotated locations for NP_796284.1

      Status: VALIDATED

      Source sequence(s)
      AC109153
      Consensus CDS
      CCDS27668.1
      UniProtKB/Swiss-Prot
      B7ZMP1
      Related
      ENSMUSP00000038331.4, OTTMUSP00000050224, ENSMUST00000041609.10
      Conserved Domains (2) summary
      smart01011
      Location:67206
      AMP_N; Aminopeptidase P, N-terminal domain
      cl00279
      Location:252352
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      81400132..81457476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521086.3XP_006521149.1  probable Xaa-Pro aminopeptidase 3 isoform X1

      Related
      ENSMUSP00000132822.1, OTTMUSP00000050223, ENSMUST00000163754.8, OTTMUST00000091221
      Conserved Domains (3) summary
      PRK10879
      Location:67499
      PRK10879; proline aminopeptidase P II; Provisional
      smart01011
      Location:67206
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:252489
      Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...
    2. XM_006521087.2XP_006521150.1  probable Xaa-Pro aminopeptidase 3 isoform X2

      See identical proteins and their annotated locations for XP_006521150.1

      Conserved Domains (3) summary
      PRK10879
      Location:2420
      PRK10879; proline aminopeptidase P II; Provisional
      smart01011
      Location:15127
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:173410
      Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...
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