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    Atad2b ATPase family, AAA domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 320817, updated on 5-Sep-2021

    Summary

    Official Symbol
    Atad2bprovided by MGI
    Official Full Name
    ATPase family, AAA domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:2444798
    See related
    Ensembl:ENSMUSG00000052812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79189; BC032887; 1110014E10Rik; D530031C13Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.7), CNS E14 (RPKM 4.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atad2b in Genome Data Viewer
    Location:
    12; 12 A1.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4964404..5097396)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4914404..5047396)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (4924159..5054216)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 2B Neighboring gene UBX domain protein 2A Neighboring gene predicted gene, 23167 Neighboring gene RAB11B, member RAS oncogene family pseudogene Neighboring gene kelch-like 29 Neighboring gene VISTA enhancer mm1338

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1240

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATPase family AAA domain-containing protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362349.1NP_001349278.1  ATPase family AAA domain-containing protein 2B

      Status: VALIDATED

      Source sequence(s)
      AC131767, CT571254
      Related
      ENSMUSP00000047445.6, ENSMUST00000045664.7
      Conserved Domains (2) summary
      cd05528
      Location:9591070
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      cl27568
      Location:396668
      TIP49; TIP49 C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4964404..5097396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515117.4XP_006515180.1  ATPase family AAA domain-containing protein 2B isoform X2

      Conserved Domains (3) summary
      cd05528
      Location:9591065
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      TIGR01243
      Location:396668
      CDC48; AAA family ATPase, CDC48 subfamily
      cl38936
      Location:768872
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_006515116.4XP_006515179.1  ATPase family AAA domain-containing protein 2B isoform X1

      Conserved Domains (4) summary
      cd05528
      Location:9581069
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG5076
      Location:8391084
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      TIGR01243
      Location:395667
      CDC48; AAA family ATPase, CDC48 subfamily
      cl38936
      Location:767871
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_030246779.1XP_030102639.1  ATPase family AAA domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      cd05528
      Location:304415
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:110252
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      COG5076
      Location:185395
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    4. XM_017315117.1XP_017170606.1  ATPase family AAA domain-containing protein 2B isoform X4

      Conserved Domains (2) summary
      cd05528
      Location:304410
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:110252
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    5. XM_036157502.1XP_036013395.1  ATPase family AAA domain-containing protein 2B isoform X3

      Conserved Domains (3) summary
      cd05528
      Location:304415
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:110252
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      COG5076
      Location:185395
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

    RNA

    1. XR_004937520.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001099628.1: Suppressed sequence

      Description
      NM_001099628.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    2. NM_177269.2: Suppressed sequence

      Description
      NM_177269.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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