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    Gfm2 G elongation factor, mitochondrial 2 [ Mus musculus (house mouse) ]

    Gene ID: 320806, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gfm2provided by MGI
    Official Full Name
    G elongation factor, mitochondrial 2provided by MGI
    Primary source
    MGI:MGI:2444783
    See related
    Ensembl:ENSMUSG00000021666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFG2; MST02; MST027; RRF2mt; EF-G2mt; 6530419G12Rik; A930009M04Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.7), kidney adult (RPKM 6.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gfm2 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97274445..97317710)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97137933..97181202)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (97907892..97951151)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene proteolipid protein 2 pseudogene Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene hexosaminidase B Neighboring gene ectodermal-neural cortex 1 Neighboring gene predicted gene, 33390

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ribosome-releasing factor 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146043.2NP_001139515.1  ribosome-releasing factor 2, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001139515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a different terminal exon for its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154620, AI666524, AK044371, AK161797
      Consensus CDS
      CCDS49338.1
      UniProtKB/Swiss-Prot
      Q8R2Q4
      UniProtKB/TrEMBL
      E9Q7N5, Q3TSU6
      Related
      ENSMUSP00000125088.2, ENSMUST00000161825.8
      Conserved Domains (1) summary
      PRK00007
      Location:66732
      PRK00007; elongation factor G; Reviewed
    2. NM_001271463.1NP_001258392.1  ribosome-releasing factor 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001258392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC154620, AK035819, AK044371
      Consensus CDS
      CCDS26708.2
      UniProtKB/Swiss-Prot
      Q8R2Q4
      Conserved Domains (1) summary
      PRK12739
      Location:66774
      PRK12739; elongation factor G; Reviewed
    3. NM_001271464.1NP_001258393.1  ribosome-releasing factor 2, mitochondrial isoform 3

      See identical proteins and their annotated locations for NP_001258393.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks an in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC154620, AK044371
      Consensus CDS
      CCDS70490.1
      UniProtKB/Swiss-Prot
      Q8R2Q4
      Related
      ENSMUSP00000048373.7, ENSMUST00000042084.13
      Conserved Domains (1) summary
      PRK12739
      Location:66747
      PRK12739; elongation factor G; Reviewed
    4. NM_001271465.1NP_001258394.1  ribosome-releasing factor 2, mitochondrial isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC154620, AK035819, AK044371
      Consensus CDS
      CCDS70491.1
      UniProtKB/Swiss-Prot
      Q8R2Q4
      Related
      ENSMUSP00000022170.8, ENSMUST00000022170.8
      Conserved Domains (6) summary
      cd01886
      Location:70350
      EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
      PRK12739
      Location:64772
      PRK12739; elongation factor G; Reviewed
      cd01693
      Location:559677
      mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...
      cd03713
      Location:682759
      EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...
      cd04092
      Location:365446
      mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
      cd16262
      Location:483558
      EFG_III; Domain III of Elongation Factor G (EFG)
    5. NM_177266.5NP_796240.3  ribosome-releasing factor 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_796240.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC154620, AK035819, AK044371
      Consensus CDS
      CCDS26708.2
      UniProtKB/Swiss-Prot
      Q8R2Q4
      Related
      ENSMUSP00000125656.2, ENSMUST00000161639.8
      Conserved Domains (1) summary
      PRK12739
      Location:66774
      PRK12739; elongation factor G; Reviewed

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      97274445..97317710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517690.5XP_006517753.1  ribosome-releasing factor 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006517753.1

      UniProtKB/Swiss-Prot
      Q8R2Q4
      Conserved Domains (1) summary
      PRK12739
      Location:66774
      PRK12739; elongation factor G; Reviewed
    2. XM_036158074.1XP_036013967.1  ribosome-releasing factor 2, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK12739
      Location:66747
      PRK12739; elongation factor G; Reviewed
    3. XM_006517691.5XP_006517754.1  ribosome-releasing factor 2, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_006517754.1

      UniProtKB/TrEMBL
      E9Q7N5
      Conserved Domains (1) summary
      PRK00007
      Location:66732
      PRK00007; elongation factor G; Reviewed
    4. XM_036158073.1XP_036013966.1  ribosome-releasing factor 2, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK12739
      Location:66747
      PRK12739; elongation factor G; Reviewed
    5. XM_030247303.2XP_030103163.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1573
      PRK12740; elongation factor G-like protein EF-G2
    6. XM_030247300.2XP_030103160.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1573
      PRK12740; elongation factor G-like protein EF-G2
    7. XM_036158075.1XP_036013968.1  ribosome-releasing factor 2, mitochondrial isoform X5

      Conserved Domains (1) summary
      PRK12740
      Location:1546
      PRK12740; elongation factor G-like protein EF-G2
    8. XM_030247302.2XP_030103162.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1573
      PRK12740; elongation factor G-like protein EF-G2
    9. XM_006517689.5XP_006517752.1  ribosome-releasing factor 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006517752.1

      UniProtKB/Swiss-Prot
      Q8R2Q4
      Conserved Domains (1) summary
      PRK12739
      Location:66774
      PRK12739; elongation factor G; Reviewed
    10. XM_030247301.2XP_030103161.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1573
      PRK12740; elongation factor G-like protein EF-G2
    11. XM_036158072.1XP_036013965.1  ribosome-releasing factor 2, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK12739
      Location:66774
      PRK12739; elongation factor G; Reviewed

    RNA

    1. XR_004938030.1 RNA Sequence

    2. XR_004938031.1 RNA Sequence

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