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    Ipo8 importin 8 [ Mus musculus (house mouse) ]

    Gene ID: 320727, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ipo8provided by MGI
    Official Full Name
    importin 8provided by MGI
    Primary source
    MGI:MGI:2444611
    See related
    Ensembl:ENSMUSG00000040029
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Om; Ra; OM-; Om1; MRP7; OM-1; Abcc10; Ranbp8; 6230418K12Rik; C130009K11Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.3), bladder adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ipo8 in Genome Data Viewer
    Location:
    6; 6 G3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148672181..148732980, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148770683..148832931, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (148719206..148779989, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528G23 gene Neighboring gene high mobility group box 1-like pseudogene Neighboring gene RIKEN cDNA 2610017A05 gene Neighboring gene caprin family member 2 Neighboring gene predicted gene, 36762

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase-coupled transmembrane transporter activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transport ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    importin-8
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
    imp8
    oocyte maturation 1
    ran-binding protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081113.1NP_001074582.1  importin-8

      See identical proteins and their annotated locations for NP_001074582.1

      Status: PROVISIONAL

      Source sequence(s)
      AC134542
      Consensus CDS
      CCDS39719.1
      UniProtKB/Swiss-Prot
      Q7TMY7
      Related
      ENSMUSP00000046759.8, ENSMUST00000048418.14
      Conserved Domains (3) summary
      COG5656
      Location:15995
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      pfam03378
      Location:626869
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam03810
      Location:22101
      IBN_N; Importin-beta N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      148672181..148732980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166241.1XP_036022134.1  importin-8 isoform X3

      Conserved Domains (1) summary
      COG5656
      Location:19933
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    2. XM_036166239.1XP_036022132.1  importin-8 isoform X1

      Conserved Domains (1) summary
      COG5656
      Location:15995
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    3. XM_036166240.1XP_036022133.1  importin-8 isoform X2

      Conserved Domains (1) summary
      COG5656
      Location:15950
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. XR_004942975.1 RNA Sequence

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