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    Pptc7 PTC7 protein phosphatase homolog [ Mus musculus (house mouse) ]

    Gene ID: 320717, updated on 22-Sep-2022


    Official Symbol
    Pptc7provided by MGI
    Official Full Name
    PTC7 protein phosphatase homologprovided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000038582 AllianceGenome:MGI:2444593
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TA-PP2C; 9130017A15Rik
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-serine dephosphorylation and regulation of ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; connective tissue; genitourinary system; and gut. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in heart adult (RPKM 24.7), adrenal adult (RPKM 19.6) and 28 other tissues See more
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    Genomic context

    See Pptc7 in Genome Data Viewer
    5; 5 F
    Exon count:
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122422461..122462344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122284398..122324281)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122734407..122774290)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1 Neighboring gene RIKEN cDNA 1700112N08 gene Neighboring gene RAD9 checkpoint clamp component B Neighboring gene VPS29 retromer complex component Neighboring gene family with sequence similarity 216, member A Neighboring gene predicted gene, 32853 Neighboring gene GPN-loop GTPase 3

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    General gene information



    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    Process Evidence Code Pubs
    involved_in peptidyl-serine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    involved_in regulation of ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    protein phosphatase PTC7 homolog
    T-cell activation protein phosphatase 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177242.4NP_796216.2  protein phosphatase PTC7 homolog

      See identical proteins and their annotated locations for NP_796216.2

      Status: PROVISIONAL

      Source sequence(s)
      AC093473, AC127266
      Consensus CDS
      Q6NVE9, Q8BVC7
      ENSMUSP00000051838.9, ENSMUST00000053426.15
      Conserved Domains (1) summary
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000071.7 Reference GRCm39 C57BL/6J

      GenBank, FASTA, Sequence Viewer (Graphics)