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    Pptc7 PTC7 protein phosphatase homolog [ Mus musculus (house mouse) ]

    Gene ID: 320717, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pptc7provided by MGI
    Official Full Name
    PTC7 protein phosphatase homologprovided by MGI
    Primary source
    MGI:MGI:2444593
    See related
    Ensembl:ENSMUSG00000038582 AllianceGenome:MGI:2444593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TA-PP2C; 9130017A15Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-serine dephosphorylation and regulation of ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; connective tissue; genitourinary system; and gut. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 24.7), adrenal adult (RPKM 19.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pptc7 in Genome Data Viewer
    Location:
    5 F; 5 62.28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122422461..122462344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122284398..122324281)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6375 Neighboring gene STARR-positive B cell enhancer ABC_E10345 Neighboring gene RIKEN cDNA 1700112N08 gene Neighboring gene STARR-seq mESC enhancer starr_14278 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122738438-122738621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122760748-122760949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122761679-122761976 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122767369-122767570 Neighboring gene RAD9 checkpoint clamp component B Neighboring gene STARR-positive B cell enhancer ABC_E2761 Neighboring gene STARR-seq mESC enhancer starr_14283 Neighboring gene VPS29 retromer complex component Neighboring gene family with sequence similarity 216, member A Neighboring gene predicted gene, 32853 Neighboring gene GPN-loop GTPase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein phosphatase PTC7 homolog
    Names
    T-cell activation protein phosphatase 2C
    NP_796216.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177242.4NP_796216.2  protein phosphatase PTC7 homolog

      See identical proteins and their annotated locations for NP_796216.2

      Status: PROVISIONAL

      Source sequence(s)
      AC093473, AC127266
      Consensus CDS
      CCDS39255.1
      UniProtKB/Swiss-Prot
      Q3TS53, Q6NVE9, Q8BVC7
      Related
      ENSMUSP00000051838.9, ENSMUST00000053426.15
      Conserved Domains (1) summary
      cl00120
      Location:66302
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122422461..122462344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)