Format

Send to:

Choose Destination
    • Showing Current items.

    Dctd dCMP deaminase [ Mus musculus (house mouse) ]

    Gene ID: 320685, updated on 14-Aug-2021

    Summary

    Official Symbol
    Dctdprovided by MGI
    Official Full Name
    dCMP deaminaseprovided by MGI
    Primary source
    MGI:MGI:2444529
    See related
    Ensembl:ENSMUSG00000031562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030466N05Rik
    Expression
    Broad expression in limb E14.5 (RPKM 14.2), CNS E11.5 (RPKM 7.8) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dctd in Genome Data Viewer
    Location:
    8; 8 B1.1- B1.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48552127..48594702)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (48099092..48141667)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (49184446..49227021)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WW, C2 and coiled-coil domain containing 2 Neighboring gene predicted gene, 31984 Neighboring gene predicted gene, 32052 Neighboring gene predicted gene, 39174 Neighboring gene predicted gene, 32194 Neighboring gene predicted gene, 51559

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dCMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyrimidine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    deoxycytidylate deaminase
    XP_006509505.1
    XP_036009996.1
    XP_036009997.1
    XP_036009998.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161515.2NP_001154987.2  deoxycytidylate deaminase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC164420
      Consensus CDS
      CCDS22302.2
      Related
      ENSMUSP00000033966.7, ENSMUST00000033966.13
      Conserved Domains (1) summary
      cd01286
      Location:17138
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    2. NM_001161516.2NP_001154988.2  deoxycytidylate deaminase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC164420
      Consensus CDS
      CCDS22302.2
      Related
      ENSMUSP00000133445.2, ENSMUST00000174278.8
      Conserved Domains (1) summary
      cd01286
      Location:17138
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    3. NM_178788.5NP_848903.3  deoxycytidylate deaminase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC164420
      Consensus CDS
      CCDS22302.2
      Related
      ENSMUSP00000126733.3, ENSMUST00000170263.9
      Conserved Domains (1) summary
      cd01286
      Location:17138
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    RNA

    1. NR_027759.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC164420, AI327164, AK077663, AV323917, BB193146, BB621273, BQ572929, BY014599
      Related
      ENSMUST00000174818.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      48552127..48594702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154105.1XP_036009998.1  deoxycytidylate deaminase isoform X1

      Conserved Domains (1) summary
      cd01286
      Location:23126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    2. XM_036154103.1XP_036009996.1  deoxycytidylate deaminase isoform X1

      Conserved Domains (1) summary
      cd01286
      Location:23126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    3. XM_036154104.1XP_036009997.1  deoxycytidylate deaminase isoform X1

      Conserved Domains (1) summary
      cd01286
      Location:23126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    4. XM_006509442.4XP_006509505.1  deoxycytidylate deaminase isoform X2

      See identical proteins and their annotated locations for XP_006509505.1

      UniProtKB/TrEMBL
      G3X908
      Conserved Domains (1) summary
      cd01286
      Location:23144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    RNA

    1. XR_003947308.2 RNA Sequence

    Support Center