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    Dctd dCMP deaminase [ Mus musculus (house mouse) ]

    Gene ID: 320685, updated on 3-Feb-2019

    Summary

    Official Symbol
    Dctdprovided by MGI
    Official Full Name
    dCMP deaminaseprovided by MGI
    Primary source
    MGI:MGI:2444529
    See related
    Ensembl:ENSMUSG00000031562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030466N05Rik
    Expression
    Broad expression in limb E14.5 (RPKM 14.2), CNS E11.5 (RPKM 7.8) and 20 other tissues See more
    Orthologs

    Genomic context

    See Dctd in Genome Data Viewer
    Location:
    8; 8 B1.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (48099092..48141667)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (49184446..49227021)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene WW, C2 and coiled-coil domain containing 2 Neighboring gene predicted gene, 31984 Neighboring gene predicted gene, 32052 Neighboring gene predicted gene, 39174 Neighboring gene predicted gene, 32194

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    dCMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    pyrimidine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    deoxycytidylate deaminase
    NP_001154987.1
    NP_001154988.1
    NP_848903.2
    XP_006509505.1
    XP_006509506.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161515.1NP_001154987.1  deoxycytidylate deaminase

      See identical proteins and their annotated locations for NP_001154987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI327164, AK039066, BB621273, BY010307
      Consensus CDS
      CCDS22302.2
      UniProtKB/Swiss-Prot
      Q8K2D6
      UniProtKB/TrEMBL
      G3X908
      Related
      ENSMUSP00000033966.6, ENSMUST00000033966.12
      Conserved Domains (1) summary
      cd01286
      Location:23144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    2. NM_001161516.1NP_001154988.1  deoxycytidylate deaminase

      See identical proteins and their annotated locations for NP_001154988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI327164, AK077663, AV323917, CO803572
      Consensus CDS
      CCDS22302.2
      UniProtKB/Swiss-Prot
      Q8K2D6
      UniProtKB/TrEMBL
      G3X908
      Related
      ENSMUSP00000133445.1, ENSMUST00000174278.7
      Conserved Domains (1) summary
      cd01286
      Location:23144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    3. NM_178788.4NP_848903.2  deoxycytidylate deaminase

      See identical proteins and their annotated locations for NP_848903.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI327164, AK031645, AK077663, AV323917, BY014599
      Consensus CDS
      CCDS22302.2
      UniProtKB/Swiss-Prot
      Q8K2D6
      UniProtKB/TrEMBL
      G3X908
      Related
      ENSMUSP00000126733.2, ENSMUST00000170263.8
      Conserved Domains (1) summary
      cd01286
      Location:23144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    RNA

    1. NR_027759.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC164420, AI327164, AK077663, AV323917, BB193146, BB621273, BQ572929, BY014599

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      48099092..48141667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509443.3XP_006509506.1  deoxycytidylate deaminase isoform X2

      See identical proteins and their annotated locations for XP_006509506.1

      UniProtKB/TrEMBL
      Q3UUA6
      Related
      ENSMUSP00000134003.1, ENSMUST00000174818.7
      Conserved Domains (1) summary
      cd01286
      Location:23126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    2. XM_006509442.3XP_006509505.1  deoxycytidylate deaminase isoform X1

      See identical proteins and their annotated locations for XP_006509505.1

      UniProtKB/TrEMBL
      G3X908
      Conserved Domains (1) summary
      cd01286
      Location:23144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
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