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    Ipcef1 interaction protein for cytohesin exchange factors 1 [ Mus musculus (house mouse) ]

    Gene ID: 320495, updated on 27-Jan-2018

    Summary

    Official Symbol
    Ipcef1provided by MGI
    Official Full Name
    interaction protein for cytohesin exchange factors 1provided by MGI
    Primary source
    MGI:MGI:2444159
    See related
    Ensembl:ENSMUSG00000064065 Vega:OTTMUSG00000022995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A130090K04Rik
    Expression
    Biased expression in cortex adult (RPKM 7.0), frontal lobe adult (RPKM 6.9) and 8 other tissues See more
    Orthologs

    Genomic context

    See Ipcef1 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (6885779..7054958, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (3323356..3460176)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46187 Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene opioid receptor, mu 1 Neighboring gene Cnksr family member 3 Neighboring gene predicted gene, 46208

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interactor protein for cytohesin exchange factors 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033391.2NP_001028563.1  interactor protein for cytohesin exchange factors 1 isoform 4

      See identical proteins and their annotated locations for NP_001028563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and 5' coding region, and uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (4) differs at the N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AK135851
      Consensus CDS
      CCDS56689.1
      UniProtKB/TrEMBL
      Q3UX69
      Related
      ENSMUSP00000128131.1, ENSMUST00000170680.7
      Conserved Domains (3) summary
      pfam00169
      Location:760
      PH; PH domain
      pfam15310
      Location:67143
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl17171
      Location:768
      PH-like; Pleckstrin homology-like domain
    2. NM_001170800.1NP_001164271.1  interactor protein for cytohesin exchange factors 1 isoform 1

      See identical proteins and their annotated locations for NP_001164271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC155718, AC164171
      Consensus CDS
      CCDS56688.1
      UniProtKB/Swiss-Prot
      Q5DU31
      Related
      ENSMUSP00000101242.1, OTTMUSP00000026512, ENSMUST00000105617.7, OTTMUST00000055375
      Conserved Domains (2) summary
      cd01260
      Location:2115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:16107
      PH; PH domain
    3. NM_001170801.1NP_001164272.1  interactor protein for cytohesin exchange factors 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and an alternate 3' splice pattern, compared to variant 1. The resulting isoform (2) includes an additional 4-aa segment and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC155718, AC164171
      Conserved Domains (3) summary
      cd01260
      Location:2115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:16107
      PH; PH domain
      pfam15310
      Location:114194
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    4. NM_001170802.1NP_001164273.1  interactor protein for cytohesin exchange factors 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC155718, AC164171
      Conserved Domains (3) summary
      cd01260
      Location:2115
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:16107
      PH; PH domain
      pfam15310
      Location:114190
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    5. NM_001347225.1NP_001334154.1  interactor protein for cytohesin exchange factors 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AA472059, AK038257, AK038911, AK135851, BQ176089, CK781068
      Consensus CDS
      CCDS83676.1
      UniProtKB/Swiss-Prot
      Q5DU31
      UniProtKB/TrEMBL
      Q3UX69

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      6885779..7054958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313967.1XP_017169456.1  interactor protein for cytohesin exchange factors 1 isoform X1

      Conserved Domains (2) summary
      cd01260
      Location:25138
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:39130
      PH; PH domain
    2. XM_011243081.1XP_011241383.1  interactor protein for cytohesin exchange factors 1 isoform X2

      Conserved Domains (2) summary
      cd01260
      Location:24137
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:38129
      PH; PH domain
    3. XM_011243080.2XP_011241382.1  interactor protein for cytohesin exchange factors 1 isoform X1

      Conserved Domains (2) summary
      cd01260
      Location:25138
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:39130
      PH; PH domain
    4. XM_011243082.2XP_011241384.1  interactor protein for cytohesin exchange factors 1 isoform X3

      Conserved Domains (2) summary
      cd01260
      Location:25138
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:39130
      PH; PH domain
    5. XM_017313968.1XP_017169457.1  interactor protein for cytohesin exchange factors 1 isoform X4

      Related
      ENSMUSP00000077215.3, OTTMUSP00000026513, ENSMUST00000078070.9, OTTMUST00000055377
    6. XM_017313969.1XP_017169458.1  interactor protein for cytohesin exchange factors 1 isoform X5

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