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    Cenpt centromere protein T [ Mus musculus (house mouse) ]

    Gene ID: 320394, updated on 9-Aug-2021

    Summary

    Official Symbol
    Cenptprovided by MGI
    Official Full Name
    centromere protein Tprovided by MGI
    Primary source
    MGI:MGI:2443939
    See related
    Ensembl:ENSMUSG00000036672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G630055P03Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 19.8), limb E14.5 (RPKM 19.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Cenpt in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106571297..106581678, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105844669..105855086, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108368578..108375908, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glucose-fructose oxidoreductase domain containing 2 Neighboring gene RAN binding protein 10 Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene THAP domain containing 11 Neighboring gene nuclear transport factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centromere protein T
    Names
    CENP-T

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177150.2NP_796124.1  centromere protein T

      See identical proteins and their annotated locations for NP_796124.1

      Status: PROVISIONAL

      Source sequence(s)
      AK090340
      Consensus CDS
      CCDS22615.1
      UniProtKB/Swiss-Prot
      Q3TJM4
      Related
      ENSMUSP00000038188.5, ENSMUST00000040776.6
      Conserved Domains (2) summary
      pfam16171
      Location:1374
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:411507
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106571297..106581678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531107.5XP_006531170.1  centromere protein T isoform X4

      See identical proteins and their annotated locations for XP_006531170.1

      Conserved Domains (2) summary
      pfam16171
      Location:1270
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:326422
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    2. XM_030243618.2XP_030099478.1  centromere protein T isoform X5

      Conserved Domains (2) summary
      pfam16171
      Location:1270
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:307403
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    3. XM_017312860.3XP_017168349.1  centromere protein T isoform X3

      Conserved Domains (2) summary
      pfam16171
      Location:12349
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:405501
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    4. XM_006531108.3XP_006531171.1  centromere protein T isoform X4

      See identical proteins and their annotated locations for XP_006531171.1

      Conserved Domains (2) summary
      pfam16171
      Location:1270
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:326422
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    5. XM_030243617.2XP_030099477.1  centromere protein T isoform X5

      Conserved Domains (2) summary
      pfam16171
      Location:1270
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:307403
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    6. XM_036154102.1XP_036009995.1  centromere protein T isoform X5

      Conserved Domains (2) summary
      pfam16171
      Location:1270
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:307403
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    7. XM_036154100.1XP_036009993.1  centromere protein T isoform X4

      Conserved Domains (2) summary
      pfam16171
      Location:1270
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:326422
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    8. XM_030243619.2XP_030099479.1  centromere protein T isoform X6

      Conserved Domains (2) summary
      pfam16171
      Location:1123
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:160256
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    9. XM_011248407.3XP_011246709.1  centromere protein T isoform X2

      See identical proteins and their annotated locations for XP_011246709.1

      UniProtKB/Swiss-Prot
      Q3TJM4
      Conserved Domains (2) summary
      pfam16171
      Location:1374
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:411507
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    10. XM_006531104.4XP_006531167.1  centromere protein T isoform X1

      Conserved Domains (2) summary
      pfam16171
      Location:1374
      CENP-T_N; Centromere kinetochore component CENP-T N-terminus
      cl23735
      Location:430526
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
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