v vermilion [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vprovided by FlyBase
Official Full Name: vermilionprovided by FlyBase
Primary source: FLYBASE:FBgn0003965
Locus tag: Dmel_CG2155
See related: AllianceGenome:FB:FBgn0003965
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 152559_at; CG2155; Crk; Dmel\CG2155; DmTDO; dYARS; Lhr; mle; NP_511113; PDFR; PKA-RII; rhoA; sda; TDO; VASA; ver; Ver; vm
Summary: Enables heme binding activity and tryptophan 2,3-dioxygenase activity. Involved in several processes, including ommochrome biosynthetic process; protein homotetramerization; and tryptophan catabolic process to kynurenine. Is expressed in embryonic head epidermis and embryonic/larval fat body. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (10923972..10925631)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (10818005..10819664)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

This study evaluated the role of the vermilion gene and its mutations on heart rate.
Title: Suppression of Tryptophan 2,3-Dioxygenase Produces a Slow Heartbeat Phenotype in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 2,3-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tryptophan 2,3-dioxygenase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in kynurenine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in tryptophan catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in tryptophan catabolic process to acetyl-CoA	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophan catabolic process to kynurenine	IDA Inferred from Direct Assay more info	PubMed
involved_in tryptophan catabolic process to kynurenine	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to kynurenine	ISS Inferred from Sequence or Structural Similarity more info