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    Senp5 SUMO/sentrin specific peptidase 5 [ Mus musculus (house mouse) ]

    Gene ID: 320213, updated on 27-Nov-2024

    Summary

    Official Symbol
    Senp5provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 5provided by MGI
    Primary source
    MGI:MGI:2443596
    See related
    Ensembl:ENSMUSG00000022772 AllianceGenome:MGI:2443596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMT3IP3; 6230429P13Rik; A730063F07Rik
    Summary
    Predicted to enable SUMO-specific endopeptidase activity and deSUMOylase activity. Predicted to be involved in protein desumoylation. Is active in postsynaptic cytosol and presynaptic cytosol. Is expressed in heart and nervous system. Orthologous to human SENP5 (SUMO specific peptidase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.7), CNS E11.5 (RPKM 4.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Senp5 in Genome Data Viewer
    Location:
    16 B2; 16 22.4 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31778488..31829388, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31959670..32003287, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Ncbp2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_40638 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene predicted gene, 26419 Neighboring gene STARR-positive B cell enhancer ABC_E7439 Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    General gene information

    Markers

    Clone Names

    • DKFZp564O1016

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sentrin-specific protease 5
    Names
    SUMO/Smt3-specific isopeptidase 3
    SUMO/sentrin specific protease 5
    sentrin/SUMO-specific protease SENP5
    NP_001344016.1
    NP_001344017.1
    NP_796077.2
    XP_006522303.1
    XP_006522305.1
    XP_036015874.1
    XP_036015875.1
    XP_036015876.1
    XP_036015877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357087.1NP_001344016.1  sentrin-specific protease 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124681
      Consensus CDS
      CCDS28111.1
      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Related
      ENSMUSP00000023457.6, ENSMUST00000023457.13
      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    2. NM_001357088.1NP_001344017.1  sentrin-specific protease 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124681
      UniProtKB/TrEMBL
      F6S6C3
      Related
      ENSMUSP00000115257.2, ENSMUST00000129900.2
      Conserved Domains (2) summary
      COG5160
      Location:567620
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    3. NM_177103.4NP_796077.2  sentrin-specific protease 5 isoform 1

      See identical proteins and their annotated locations for NP_796077.2

      Status: VALIDATED

      Source sequence(s)
      AC124681, AK028177, BC067014, BG146216
      Consensus CDS
      CCDS28111.1
      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Related
      ENSMUSP00000156109.2, ENSMUST00000231360.2
      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31778488..31829388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159982.1XP_036015875.1  sentrin-specific protease 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    2. XM_036159981.1XP_036015874.1  sentrin-specific protease 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    3. XM_006522242.5XP_006522305.1  sentrin-specific protease 5 isoform X3

      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (1) summary
      COG5160
      Location:567702
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    4. XM_036159983.1XP_036015876.1  sentrin-specific protease 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    5. XM_036159984.1XP_036015877.1  sentrin-specific protease 5 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:6187
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    6. XM_006522240.5XP_006522303.1  sentrin-specific protease 5 isoform X2

      Conserved Domains (1) summary
      cl23802
      Location:591721
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RNA

    1. XR_004939195.1 RNA Sequence

    2. XR_003951796.2 RNA Sequence

    3. XR_004939194.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023801.1: Suppressed sequence

      Description
      NM_023801.1: This RefSeq was permanently suppressed because it is entirely UTR sequence.