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    Senp5 SUMO/sentrin specific peptidase 5 [ Mus musculus (house mouse) ]

    Gene ID: 320213, updated on 8-Jul-2021

    Summary

    Official Symbol
    Senp5provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 5provided by MGI
    Primary source
    MGI:MGI:2443596
    See related
    Ensembl:ENSMUSG00000022772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMT3IP3; AI851888; BB189556; 6230429P13Rik; A730063F07Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.7), CNS E11.5 (RPKM 4.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Senp5 in Genome Data Viewer
    Location:
    16; 16 B2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31778488..31829388, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31959670..32003287, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (31959756..32003373, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610012G03 gene Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene predicted gene, 26419 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp564O1016

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like protein-specific protease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sentrin-specific protease 5
    Names
    SUMO/Smt3-specific isopeptidase 3
    SUMO/sentrin specific protease 5
    sentrin/SUMO-specific protease SENP5
    NP_001344016.1
    NP_001344017.1
    NP_796077.2
    XP_006522303.1
    XP_006522305.1
    XP_036015874.1
    XP_036015875.1
    XP_036015876.1
    XP_036015877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357087.1NP_001344016.1  sentrin-specific protease 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124681
      Consensus CDS
      CCDS28111.1
      Related
      ENSMUSP00000023457.6, ENSMUST00000023457.13
      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    2. NM_001357088.1NP_001344017.1  sentrin-specific protease 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124681
      Related
      ENSMUSP00000115257.2, ENSMUST00000129900.2
      Conserved Domains (1) summary
      COG5160
      Location:567620
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    3. NM_177103.4NP_796077.2  sentrin-specific protease 5 isoform 1

      See identical proteins and their annotated locations for NP_796077.2

      Status: VALIDATED

      Source sequence(s)
      AC124681, AK028177, BC067014, BG146216
      Consensus CDS
      CCDS28111.1
      UniProtKB/Swiss-Prot
      Q6NXL6
      Related
      ENSMUSP00000156109.2, ENSMUST00000231360.2
      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31778488..31829388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159982.1XP_036015875.1  sentrin-specific protease 5 isoform X1

      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    2. XM_036159981.1XP_036015874.1  sentrin-specific protease 5 isoform X1

      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    3. XM_006522242.5XP_006522305.1  sentrin-specific protease 5 isoform X3

      Conserved Domains (1) summary
      COG5160
      Location:567702
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    4. XM_036159983.1XP_036015876.1  sentrin-specific protease 5 isoform X1

      Conserved Domains (2) summary
      pfam02902
      Location:575747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488545
      DEK_C; DEK C terminal domain
    5. XM_036159984.1XP_036015877.1  sentrin-specific protease 5 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:6187
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    6. XM_006522240.5XP_006522303.1  sentrin-specific protease 5 isoform X2

      Conserved Domains (1) summary
      cl23802
      Location:591721
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RNA

    1. XR_004939195.1 RNA Sequence

    2. XR_003951796.2 RNA Sequence

    3. XR_004939194.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023801.1: Suppressed sequence

      Description
      NM_023801.1: This RefSeq was permanently suppressed because it is entirely UTR sequence.
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