U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tacc1 transforming, acidic coiled-coil containing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 320165, updated on 26-Sep-2022

    Summary

    Official Symbol
    Tacc1provided by MGI
    Official Full Name
    transforming, acidic coiled-coil containing protein 1provided by MGI
    Primary source
    MGI:MGI:2443510
    See related
    Ensembl:ENSMUSG00000065954 AllianceGenome:MGI:2443510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833447E04Rik; B230378H13Rik
    Summary
    Enables nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein domain specific binding activity. Acts upstream of or within microtubule cytoskeleton organization; nervous system development; and regulation of microtubule-based process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and respiratory system. Orthologous to human TACC1 (transforming acidic coiled-coil containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.7), bladder adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tacc1 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25644568..25746440, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25154552..25256424, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 Neighboring gene RIKEN cDNA 5830408C22 gene Neighboring gene predicted gene, 39143 Neighboring gene microRNA 8108 Neighboring gene predicted gene, 39144 Neighboring gene predicted gene, 39145 Neighboring gene RIKEN cDNA 5430421F17 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 4833447E04Rik, B230378H13Rik

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transforming acidic coiled-coil-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402841.1NP_001389770.1  transforming acidic coiled-coil-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114589
    2. NM_001402842.1NP_001389771.1  transforming acidic coiled-coil-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114589
    3. NM_001402843.1NP_001389772.1  transforming acidic coiled-coil-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC114589
    4. NM_177089.6NP_796063.3  transforming acidic coiled-coil-containing protein 1 long isoform

      See identical proteins and their annotated locations for NP_796063.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the long isoform.
      Source sequence(s)
      AC114589
      Consensus CDS
      CCDS40303.1
      UniProtKB/Swiss-Prot
      Q6Y685
      UniProtKB/TrEMBL
      F8VQ95
      Related
      ENSMUSP00000081043.5, ENSMUST00000084030.6
      Conserved Domains (3) summary
      pfam05010
      Location:570769
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:675768
      FadA; Adhesion protein FadA
      cl21478
      Location:577662
      ATP-synt_B; ATP synthase B/B' CF(0)
    5. NM_199323.4NP_955355.1  transforming acidic coiled-coil-containing protein 1 short isoform

      See identical proteins and their annotated locations for NP_955355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes the short isoform, compared to the long isoform.
      Source sequence(s)
      AC114589
      Consensus CDS
      CCDS40302.1
      UniProtKB/Swiss-Prot
      Q6Y685
      Related
      ENSMUSP00000081560.5, ENSMUST00000084512.11
      Conserved Domains (1) summary
      pfam05010
      Location:162361
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25644568..25746440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312859.2XP_017168348.1  transforming acidic coiled-coil-containing protein 1 isoform X5

      Conserved Domains (2) summary
      pfam05010
      Location:401600
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam15740
      Location:48211
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    2. XM_006509146.5XP_006509209.1  transforming acidic coiled-coil-containing protein 1 isoform X7

      Conserved Domains (1) summary
      pfam05010
      Location:121320
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    3. XM_030243614.1XP_030099474.1  transforming acidic coiled-coil-containing protein 1 isoform X4

      Conserved Domains (2) summary
      pfam05010
      Location:552751
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam15740
      Location:199362
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    4. XM_030243613.2XP_030099473.1  transforming acidic coiled-coil-containing protein 1 isoform X2

      Conserved Domains (2) summary
      pfam05010
      Location:540739
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam15740
      Location:199362
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    5. XM_036154099.1XP_036009992.1  transforming acidic coiled-coil-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam05010
      Location:479678
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    6. XM_030243615.2XP_030099475.1  transforming acidic coiled-coil-containing protein 1 isoform X6

      Conserved Domains (1) summary
      pfam05010
      Location:132331
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    7. XM_006509143.4XP_006509206.1  transforming acidic coiled-coil-containing protein 1 isoform X1

      Conserved Domains (2) summary
      pfam05010
      Location:582781
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam15740
      Location:229392
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus