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    Taf2 TATA-box binding protein associated factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 319944, updated on 27-Nov-2024

    Summary

    Official Symbol
    Taf2provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 2provided by MGI
    Primary source
    MGI:MGI:2443028
    See related
    Ensembl:ENSMUSG00000037343 AllianceGenome:MGI:2443028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAF2B; CIF150; TAFII150; TAFII-150; 4732460C16Rik
    Summary
    Predicted to enable chromatin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex and transcription factor TFTC complex. Is expressed in tail. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 40. Orthologous to human TAF2 (TATA-box binding protein associated factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.6), CNS E14 (RPKM 10.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Taf2 in Genome Data Viewer
    Location:
    15 D1; 15 21.96 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54878525..54935580, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55015129..55072187, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38694 Neighboring gene predicted gene, 26684 Neighboring gene predicted gene 2491 Neighboring gene STARR-positive B cell enhancer mm9_chr15:54903568-54903869 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene predicted gene, 41325 Neighboring gene STARR-positive B cell enhancer ABC_E3139 Neighboring gene predicted gene 9920 Neighboring gene DEP domain containing MTOR-interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 2
    Names
    TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor
    TBP-associated factor 150 kDa
    transcription initiation factor TFIID 150 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081288.1NP_001074757.1  transcription initiation factor TFIID subunit 2

      See identical proteins and their annotated locations for NP_001074757.1

      Status: VALIDATED

      Source sequence(s)
      AC137950
      Consensus CDS
      CCDS37075.1
      UniProtKB/Swiss-Prot
      Q8BKQ7, Q8C176
      UniProtKB/TrEMBL
      B9EJX5
      Related
      ENSMUSP00000043733.8, ENSMUST00000041733.9
      Conserved Domains (1) summary
      cd09839
      Location:27541
      M1_TAF2; TATA binding protein (TBP) associated factor 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      54878525..54935580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245657.4XP_011243959.1  transcription initiation factor TFIID subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BKQ7, Q8C176
      Conserved Domains (1) summary
      cd09839
      Location:28527
      M1_like_TAF2; TATA binding protein (TBP) associated factor 2
    2. XM_006521076.5XP_006521139.1  transcription initiation factor TFIID subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8BKQ7, Q8C176
      Conserved Domains (1) summary
      cd09839
      Location:28523
      M1_like_TAF2; TATA binding protein (TBP) associated factor 2

    RNA

    1. XR_001781544.3 RNA Sequence

    2. XR_001781543.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177040.3: Suppressed sequence

      Description
      NM_177040.3: This RefSeq was removed because it was based on a cloning artifact.