Format

Send to:

Choose Destination
    • Showing Current items.

    Sbf2 SET binding factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 319934, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sbf2provided by MGI
    Official Full Name
    SET binding factor 2provided by MGI
    Primary source
    MGI:MGI:1921831
    See related
    Ensembl:ENSMUSG00000038371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SBF; Mtmr1; Mtmr13; mMTMH1; AA414977; AI317167; 4833411B01Rik; B430219L04Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.7), whole brain E14.5 (RPKM 16.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sbf2 in Genome Data Viewer
    Location:
    7; 7 E3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109907218..110215150, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110308011..110614934, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (117451527..117758434, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32861 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene predicted gene 10087 Neighboring gene ribosomal protein S8, pseudogene 1 pseudogene Neighboring gene predicted gene, 46027 Neighboring gene predicted gene 28863 Neighboring gene adrenomedullin Neighboring gene predicted gene, 21123

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myotubularin-related protein 13
    Names
    inactive phosphatidylinositol 3-phosphatase 13
    myotubularin related protein 13
    myotubularin-related protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177324.2NP_796298.2  myotubularin-related protein 13

      Status: VALIDATED

      Source sequence(s)
      AK029568, AK046622, AK080952, CD538190, CF745183, CJ314941, CO433861
      Consensus CDS
      CCDS52361.1
      UniProtKB/TrEMBL
      E9PXF8, Q8BJ67, Q8BJP4
      Related
      ENSMUSP00000033058.8, ENSMUST00000033058.14
      Conserved Domains (7) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17651870
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein
      cl28904
      Location:11361508
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109907218..110215150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507926.3XP_006507989.1  myotubularin-related protein 13 isoform X5

      UniProtKB/TrEMBL
      E9Q305
      Related
      ENSMUSP00000132072.2, ENSMUST00000164759.8
      Conserved Domains (7) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17401845
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein
      cl28904
      Location:11361483
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. XM_006507925.3XP_006507988.1  myotubularin-related protein 13 isoform X3

      Conserved Domains (7) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17721877
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein
      cl28904
      Location:11361515
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    3. XM_006507927.4XP_006507990.1  myotubularin-related protein 13 isoform X1

      Conserved Domains (7) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17971902
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein
      cl28904
      Location:11361540
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    4. XM_030242673.2XP_030098533.1  myotubularin-related protein 13 isoform X6

      Conserved Domains (7) summary
      smart00801
      Location:351419
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:186
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17391844
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:879997
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam02141
      Location:115297
      DENN; DENN (AEX-3) domain
      pfam12335
      Location:530751
      SBF2; Myotubularin protein
      cl28904
      Location:11351482
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    5. XM_030242672.2XP_030098532.1  myotubularin-related protein 13 isoform X4

      Conserved Domains (7) summary
      smart00801
      Location:351419
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:186
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17641869
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:879997
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam02141
      Location:115297
      DENN; DENN (AEX-3) domain
      pfam12335
      Location:530751
      SBF2; Myotubularin protein
      cl28904
      Location:11351507
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    6. XM_006507924.3XP_006507987.1  myotubularin-related protein 13 isoform X2

      Conserved Domains (7) summary
      smart00801
      Location:351419
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:186
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17961901
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:879997
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam02141
      Location:115297
      DENN; DENN (AEX-3) domain
      pfam12335
      Location:530751
      SBF2; Myotubularin protein
      cl28904
      Location:11351539
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    7. XM_011241830.3XP_011240132.1  myotubularin-related protein 13 isoform X7

      Conserved Domains (6) summary
      smart00801
      Location:108176
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:15531658
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:636754
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam12335
      Location:287508
      SBF2; Myotubularin protein
      cl11519
      Location:154
      DENN; DENN (AEX-3) domain
      cl28904
      Location:8921296
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_001785572.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178769.2: Suppressed sequence

      Description
      NM_178769.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Support Center