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    Sbf2 SET binding factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 319934, updated on 5-Aug-2018

    Summary

    Official Symbol
    Sbf2provided by MGI
    Official Full Name
    SET binding factor 2provided by MGI
    Primary source
    MGI:MGI:1921831
    See related
    Ensembl:ENSMUSG00000038371 Vega:OTTMUSG00000036532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtmr13; mMTMH1; AA414977; AI317167; 4833411B01Rik; B430219L04Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.7), whole brain E14.5 (RPKM 16.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sbf2 in Genome Data Viewer
    Location:
    7; 7 E3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (110308011..110614953, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (117451527..117758434, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32861 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene predicted gene 10087 Neighboring gene ribosomal protein S8, pseudogene 1 pseudogene Neighboring gene predicted gene, 46027 Neighboring gene adrenomedullin Neighboring gene predicted gene, 21123

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rab guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    protein tetramerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myotubularin-related protein 13
    Names
    myotubularin related protein 13
    myotubularin-related protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177324.2NP_796298.2  myotubularin-related protein 13

      Status: VALIDATED

      Source sequence(s)
      AK029568, AK046622, AK080952, CD538190, CF745183, CJ314941, CO433861
      Consensus CDS
      CCDS52361.1
      UniProtKB/TrEMBL
      E9PXF8, Q8BJ67, Q8BJP4
      Related
      ENSMUSP00000033058.7, ENSMUST00000033058.13
      Conserved Domains (8) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17651870
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:17701870
      PH; PH domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam06602
      Location:11141542
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      110308011..110614953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507927.2XP_006507990.1  myotubularin-related protein 13 isoform X4

      Conserved Domains (8) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17971902
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:18021902
      PH; PH domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam06602
      Location:11141574
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein
    2. XM_006507926.1XP_006507989.1  myotubularin-related protein 13 isoform X3

      UniProtKB/TrEMBL
      E9Q305
      Related
      ENSMUSP00000132072.1, OTTMUSP00000052015, ENSMUST00000164759.7, OTTMUST00000093662
      Conserved Domains (8) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17401845
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:17451845
      PH; PH domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam06602
      Location:11141517
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein
    3. XM_006507925.1XP_006507988.1  myotubularin-related protein 13 isoform X2

      Conserved Domains (8) summary
      smart00801
      Location:352420
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:187
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17721877
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:880998
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:17771877
      PH; PH domain
      pfam02141
      Location:116298
      DENN; DENN (AEX-3) domain
      pfam06602
      Location:11141549
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:531752
      SBF2; Myotubularin protein
    4. XM_006507924.1XP_006507987.1  myotubularin-related protein 13 isoform X1

      Conserved Domains (8) summary
      smart00801
      Location:351419
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:186
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:17961901
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:879997
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:18011901
      PH; PH domain
      pfam02141
      Location:115297
      DENN; DENN (AEX-3) domain
      pfam06602
      Location:11131573
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:530751
      SBF2; Myotubularin protein
    5. XM_011241830.2XP_011240132.1  myotubularin-related protein 13 isoform X5

      Conserved Domains (7) summary
      smart00801
      Location:108176
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      cd01235
      Location:15531658
      PH_Sbf1_hMTMR5; Set binding factor 1 (also called Human MTMR5) Pleckstrin Homology (PH) domain
      cd13339
      Location:636754
      PH-GRAM_MTMR13; Myotubularian (MTM) related 13 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam00169
      Location:15581658
      PH; PH domain
      pfam06602
      Location:8701330
      Myotub-related; Myotubularin-like phosphatase domain
      pfam12335
      Location:287508
      SBF2; Myotubularin protein
      cl11519
      Location:154
      DENN; DENN (AEX-3) domain

    RNA

    1. XR_001785572.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178769.2: Suppressed sequence

      Description
      NM_178769.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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