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    Tigar Trp53 induced glycolysis repulatory phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 319801, updated on 5-Feb-2019

    Summary

    Official Symbol
    Tigarprovided by MGI
    Official Full Name
    Trp53 induced glycolysis repulatory phosphataseprovided by MGI
    Primary source
    MGI:MGI:2442752
    See related
    Ensembl:ENSMUSG00000038028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79710; C85509; AA793651; AI595337; 9630033F20Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 8.1), cerebellum adult (RPKM 5.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tigar in Genome Data Viewer
    Location:
    6; 6 F3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (127085116..127109552, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (127035134..127059570, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 6 Neighboring gene fibroblast growth factor 23 Neighboring gene cyclin D2 Neighboring gene RIKEN cDNA 9330179D12 gene Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    bisphosphoglycerate 2-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    fructose-2,6-bisphosphate 2-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fructose-2,6-bisphosphate 2-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cobalt ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    fructose 2,6-bisphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fructose 2,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose catabolic process to lactate via pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hexokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of response to DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ischemia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fructose-2,6-bisphosphatase TIGAR
    Names
    TP53-induced glycolysis and apoptosis regulator
    TP53-induced glycolysis regulatory phosphatase
    probable fructose-2,6-bisphosphatase TIGAR
    NP_795977.1
    XP_006506317.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177003.5NP_795977.1  fructose-2,6-bisphosphatase TIGAR

      See identical proteins and their annotated locations for NP_795977.1

      Status: VALIDATED

      Source sequence(s)
      AC163683, AK145896
      Consensus CDS
      CCDS20563.1
      UniProtKB/Swiss-Prot
      Q8BZA9
      UniProtKB/TrEMBL
      B2RWB7
      Related
      ENSMUSP00000048643.8, ENSMUST00000039913.8
      Conserved Domains (1) summary
      pfam00300
      Location:6241
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      127085116..127109552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506254.1XP_006506317.1  fructose-2,6-bisphosphatase TIGAR isoform X1

      Conserved Domains (1) summary
      cl11399
      Location:1163
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
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