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    Tigar Trp53 induced glycolysis regulatory phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 319801, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tigarprovided by MGI
    Official Full Name
    Trp53 induced glycolysis regulatory phosphataseprovided by MGI
    Primary source
    MGI:MGI:2442752
    See related
    Ensembl:ENSMUSG00000038028 AllianceGenome:MGI:2442752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630033F20Rik
    Summary
    Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in negative regulation of neuron death and response to ischemia. Acts upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Located in mitochondrion. Is expressed in brain; immune system; and liver. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 8.1), cerebellum adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tigar in Genome Data Viewer
    Location:
    6 F3; 6 61.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127062079..127086564, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127085116..127109552, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 6 Neighboring gene fibroblast growth factor 23 Neighboring gene STARR-seq mESC enhancer starr_17405 Neighboring gene STARR-positive B cell enhancer ABC_E2208 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:127059715-127059898 Neighboring gene STARR-seq mESC enhancer starr_17406 Neighboring gene cyclin D2 Neighboring gene RIKEN cDNA 9330179D12 gene Neighboring gene STARR-positive B cell enhancer ABC_E2805 Neighboring gene STARR-positive B cell enhancer ABC_E9676 Neighboring gene STARR-seq mESC enhancer starr_17407 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables fructose-2,6-bisphosphate 2-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cobalt ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cobalt ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of glucose catabolic process to lactate via pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within intestinal epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hexokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hexokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of pentose-phosphate shunt IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of pentose-phosphate shunt ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of response to DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of response to DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ischemia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    fructose-2,6-bisphosphatase TIGAR
    Names
    TP53-induced glycolysis and apoptosis regulator
    TP53-induced glycolysis regulatory phosphatase
    Trp53 induced glycolysis repulatory phosphatase
    probable fructose-2,6-bisphosphatase TIGAR
    NP_795977.1
    XP_006506317.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177003.5NP_795977.1  fructose-2,6-bisphosphatase TIGAR

      See identical proteins and their annotated locations for NP_795977.1

      Status: VALIDATED

      Source sequence(s)
      AC163683, AK145896
      Consensus CDS
      CCDS20563.1
      UniProtKB/Swiss-Prot
      Q8BZA9
      UniProtKB/TrEMBL
      B2RWB7
      Related
      ENSMUSP00000048643.9, ENSMUST00000039913.9
      Conserved Domains (1) summary
      pfam00300
      Location:6241
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      127062079..127086564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506254.2XP_006506317.1  fructose-2,6-bisphosphatase TIGAR isoform X1

      Conserved Domains (1) summary
      cl11399
      Location:1163
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction