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    Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 319765, updated on 30-Oct-2018

    Summary

    Official Symbol
    Igf2bp2provided by MGI
    Official Full Name
    insulin-like growth factor 2 mRNA binding protein 2provided by MGI
    Primary source
    MGI:MGI:1890358
    See related
    Ensembl:ENSMUSG00000033581 Vega:OTTMUSG00000025859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp2; IMP-2; Neilsen; C330012H03Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 16.2), limb E14.5 (RPKM 16.1) and 17 other tissues See more
    Orthologs

    Genomic context

    See Igf2bp2 in Genome Data Viewer
    Location:
    16; 16 B1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (22059009..22163299, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (22059082..22163372, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A11B Neighboring gene transmembrane protein 97 pseudogene Neighboring gene predicted gene, 36796

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    insulin-like growth factor 2 mRNA-binding protein 2
    Names
    IGF-II mRNA-binding protein 2
    IGF2 mRNA-binding protein 2
    VICKZ family member 2
    insulin-like growth factor 2, binding protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183029.2NP_898850.2  insulin-like growth factor 2 mRNA-binding protein 2

      See identical proteins and their annotated locations for NP_898850.2

      Status: VALIDATED

      Source sequence(s)
      BC054552, BU708344, BY512142, CB290059
      Consensus CDS
      CCDS49797.1
      UniProtKB/Swiss-Prot
      Q5SF07
      Related
      ENSMUSP00000097629.4, OTTMUSP00000031555, ENSMUST00000100052.10, OTTMUST00000063721
      Conserved Domains (6) summary
      COG0724
      Location:378
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00105
      Location:270335
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:422486
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cl02570
      Location:316381
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17169
      Location:82157
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      22059009..22163299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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