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    Pdpr pyruvate dehydrogenase phosphatase regulatory subunit [ Mus musculus (house mouse) ]

    Gene ID: 319518, updated on 3-Feb-2019

    Summary

    Official Symbol
    Pdprprovided by MGI
    Official Full Name
    pyruvate dehydrogenase phosphatase regulatory subunitprovided by MGI
    Primary source
    MGI:MGI:2442188
    See related
    Ensembl:ENSMUSG00000033624
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU018056; mKIAA1990; 4930402E16Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 14.4), kidney adult (RPKM 8.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pdpr in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (111094606..111139781)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (113618645..113659044)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene C-type lectin domain family 18, member A Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene ring finger and WD repeat domain 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
    NP_938050.1
    XP_006531147.1
    XP_017168341.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198308.1NP_938050.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_938050.1

      Status: PROVISIONAL

      Source sequence(s)
      AY223867
      Consensus CDS
      CCDS22670.1
      UniProtKB/Swiss-Prot
      Q7TSQ8
      Related
      ENSMUSP00000046639.3, ENSMUST00000039333.9
      Conserved Domains (5) summary
      COG0404
      Location:452867
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:44384
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:462735
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:747851
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:405459
      FAO_M; FAD dependent oxidoreductase central domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      111094606..111139781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531084.3XP_006531147.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006531147.1

      UniProtKB/Swiss-Prot
      Q7TSQ8
      Conserved Domains (5) summary
      COG0404
      Location:452867
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01266
      Location:44384
      DAO; FAD dependent oxidoreductase
      pfam01571
      Location:462735
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:747851
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:405459
      FAO_M; FAD dependent oxidoreductase central domain
    2. XM_017312852.1XP_017168341.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

      Conserved Domains (4) summary
      COG0404
      Location:51466
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      pfam01571
      Location:61334
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:346450
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:458
      FAO_M; FAD dependent oxidoreductase central domain
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